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首页> 外文期刊>Neuron >Sleep and Movement Differentiates Actions of Two Types of Somatostatin-Expressing GABAergic Interneuron in Rat Hippocampus
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Sleep and Movement Differentiates Actions of Two Types of Somatostatin-Expressing GABAergic Interneuron in Rat Hippocampus

机译：睡眠和运动区分大鼠海马中两种表达促生长素抑制素的GABA能中间神经元的作用。

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摘要

Neuropeptides acting on pre- and postsynaptic receptors are coreleased with GABA by interneurons including bistratified and O-LM cells, both expressing somatostatin but innervating segregated dendritic domains of pyramidal cells. Neuropeptide release requires high-frequency action potentials, but the firing patterns of most peptide/GABA-releasing interneurons during behavior are unknown. We show that behavioral and network states differentiate the activities of bistratified and O-LM cells in freely moving rats. Bistratified cells fire at higher rates during sleep than O-LM cells and, unlike O-LM cells, strongly increase spiking during sharp wave-associated ripples (SWRs). In contrast, O-LM interneurons decrease firing during sleep relative to awake states and are mostly inhibited during SWRs. During movement, both cell types fire cooperatively at the troughs of theta oscillations but with different frequencies. Somatostatin and GABA are differentially released to distinct dendritic zones of CA1 pyramidal cells during sleep and wakefulness to coordinate segregated glutamatergic inputs from entorhinal cortex and CA3.
机译：作用于突触前和突触后受体的神经肽由包括双分层细胞和O-LM细胞在内的中间神经元与GABA共释放，两者均表达生长抑素但支配着锥体细胞的分离树突结构域。神经肽的释放需要高频动作电位，但是行为过程中大多数释放肽/ GABA的中间神经元的激发方式尚不清楚。我们显示行为和网络状态区分自由移动大鼠中的双分层和O-LM细胞的活动。受精化的细胞在睡眠期间以比O-LM细胞更高的速率发射，并且与O-LM细胞不同，在尖锐的波相关波纹（SWR）中强烈增强了尖峰。相反，相对于清醒状态，O-LM中间神经元降低了睡眠时的放电，并且在SWR期间大部分被抑制。在移动过程中，两种细胞类型在θ振荡的波谷处协同发射，但频率不同。生长抑素和GABA在睡眠和清醒期间差异释放到CA1锥体细胞的不同树突区域，以协调来自内嗅皮层和CA3的分离的谷氨酸能输入。

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