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首页> 外文期刊>Neuron >Local Postsynaptic Voltage-Gated Sodium Channel Activation in Dendritic Spines of Olfactory Bulb Granule Cells
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Local Postsynaptic Voltage-Gated Sodium Channel Activation in Dendritic Spines of Olfactory Bulb Granule Cells

机译：嗅球颗粒细胞的树突棘中的局部突触后电压门控钠通道激活。

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Neuronal dendritic spines have been speculated to function as independent computational units, yet evidence for active electrical computation in spines is scarce. Here we show that strictly local voltage-gated sodium channel (Na-v) activation can occur during excitatory postsynaptic potentials in the spines of olfactory bulb granule cells, which we mimic and detect via combined two-photon uncaging of glutamate and calcium imaging in conjunction with whole-cell recordings. We find that local Na-v activation boosts calcium entry into spines through high-voltage-activated calcium channels and accelerates postsynaptic somatic depolarization, without affecting NMDA receptor-mediated signaling. Hence, Na-v-mediated boosting promotes rapid output from the reciprocal granule cell spine onto the lateral mitral cell dendrite and thus can speed up recurrent inhibition. This striking example of electrical compartmentalization both adds to the understanding of olfactory network processing and broadens the general view of spine function.
机译：已经推测神经元树突棘可作为独立的计算单位发挥作用，但很少有证据证明在棘突中进行主动电计算。在这里，我们显示，嗅球颗粒细胞的棘突在兴奋性突触后电位期间可能会发生严格的局部电压门控钠通道（Na-v）激活，我们通过结合谷氨酸和钙成像的双光子解开联合模拟和检测与全细胞录音。我们发现，局部Na-v激活通过高压激活的钙通道促进钙进入棘突并加速突触后体细胞去极化，而不影响NMDA受体介导的信号传导。因此，Na-v介导的促进作用促进了相互颗粒细胞脊柱的快速输出到二尖瓣外侧细胞树突，从而可以加快复发抑制。电气分隔的醒目示例既增加了对嗅觉网络处理的理解，又拓宽了脊柱功能的一般视野。

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