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首页> 外文期刊>Global journal of medicine and public health. >Seroprevalence of Herpes Simplex Virus type-2 and risk factors among HIV infected and uninfected individuals in North India
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Seroprevalence of Herpes Simplex Virus type-2 and risk factors among HIV infected and uninfected individuals in North India

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BackgroundOpportunistic infections (OIs) continue to be one of the most universalcomplications of HIV infected patients. In recent years, an interestingepidemiological association has emerged between herpes simplex virus type2(HSV-2) and HIV infection. HSV-2 seroprevalence rates are higher in HIVseropositive individuals than in those who are HIV seronegative.MethodA prospective observational study was conducted at a tertiary care hospital inNorth India, to determine the seroprevalence of HSV-2 infection among HIVinfected and uninfected individuals, and to assess their risk behaviour. Thestudy group comprised 240 subjects:Group A (Cases) – 120 HIV seropositive clients/patients.Group B (Controls) – 120 age/sex matched HIV seronegative clients/patients.HIV testing was carried out as per National AIDS Control Organisation (NACO)guidelines using E/R (ELISA/Rapid) tests. HSV-2 IgM and IgG antibodydetection was carried out using HSV-2 IgM and IgG ELISA based kits.ResultsOnly one subject in Group A tested HSV-2 IgM seropositive, whereas all Group B subjects were HSV-2 IgMseronegative. The number of HSV-2 IgG seropositive subjects in Group A was significantly higher (p0.02) thanthe seropositive subjects in Group B, and the number of seronegative subjects was significantly higher (p0.01)in Group B compared to Group A. On analyzing the sexual behaviour risk factors, it was found that subjects witha history of multiple sexual partners was significantly higher (p0.007) in Group A than in Group B.ConclusionHSV-2 IgG seropositivity was significantly higher in group A as compared to Group B. The significantly highernumber of HSV-2 IgG seropositive subjects in Group A had a history of unprotected sexual contacts, multiplesexual partners and were more likely to have an HIV positive spouse or parent.

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