Non-inhibitory effects of the potent antioxidant C-phycocyanin from Plectonema sp. on the in vitro glycation reaction

Arbab Husain; Sultan Alouffi; Afreen KhanamRihab AkashaSaif KhanMahvish KhanAlvina FarooquiSaheem Ahmad

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Non-inhibitory effects of the potent antioxidant C-phycocyanin from Plectonema sp. on the in vitro glycation reaction

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When glucose and Amadori products are auto-oxidized, glycation occurs, resulting in the formation of early (Amadori) and late advanced glycation end products (AGEs), as well as free radicals. Glycation and an increase in free radical activity induce diabetic complications. Antioxidant and antiglycation compounds may aid in the prevention of oxidation and glycation. The goal of this study was to assess the antiglycation and antioxidant capacity of C-phycocyanin (C-PC) derived from Plectonema sp. The DPPH (1, 1-diphenyl-2-picrylhydrazyl), nitric oxide, hydroxyl radical scavenging activities and ferric ions reducing antioxidant power (FRAP) assays were used to assess antioxidant activity, while an in vitro bovine serum albumin-methyl glyoxal glycation (BSA-MG) model was used to assess glycation inhibitory potential. Glycation inhibition was measured using a variety of spectroscopic and biochemical parameters, including UV-visible amp; fluorescence spectroscopy, ketoamine, carbonyl and hydroxymethyl furfural content, as well as free lysine amp; free arginine estimations. In vitro, C-PC exhibited dose-dependent potent antioxidant activity, but lacked significant antiglycation potential. As a result, it is recommended that further studies be conducted to evaluate the antiglycation potential of C-PC.

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《Romanian Journal of Laboratory Medicine》 |2022年第2期|199-213|共15页
作者
Arbab Husain; Sultan Alouffi; Afreen KhanamRihab AkashaSaif KhanMahvish KhanAlvina FarooquiSaheem Ahmad;
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作者单位

Department of Biosciences, Integral University;

Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Hail;

Molecular Diagnostic &

Personalized Therapeutic Unit, University of HailDepartment of Basic Dental and Medical Sciences, College of Dentistry, University of HailDepartment of Biology, College of Science, University of HailDepartment of Bioengineering, Integral University;

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正文语种英语
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glycation; antioxidant; antiglycation; plectonema sp.; C-phycocyanin; Bovine Serum Albumin (BSA); Methylglyoxal (MG);

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Non-inhibitory effects of the potent antioxidant C-phycocyanin from Plectonema sp. on the in vitro glycation reaction

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