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首页> 外文期刊>Neuropsychologia >Verbal fluency in Parkinson's disease patients on/off dopamine medication
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Verbal fluency in Parkinson's disease patients on/off dopamine medication

机译：开/关多巴胺药物治疗帕金森氏病患者的口语流利度

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Introduction: Parkinson's disease (PD) is associated with dopamine depletion in the fronto-striatal network which affects some language aspects such as verb processing. Some experiments have demonstrated that dopamine deficiency plays a role in the normal functioning of the lexico-semantic system. As a result, the verbal fluency task could be a useful tool to assess the function of the semantic system, by examining both the number of words generated and the frequency of use of those words. Objective: The aim of this study was to find out how dopamine affects the performance of PD patients using a verbal fluency task, focussing on action-word fluency. Method: A group of 20 PD patients and 20 controls participated in the study. Participants were assessed with four different verbal fluency tasks: phonological, semantic (animal and supermarket words) and action fluency. PD patients were tested twice (on/off medication) and controls only once. Results: For the number of words, there were significant differences between PD patients on and off medication in the phonological and action fluency tasks. Compared to controls, PD off medication produced significantly fewer words in phonological, and actions. Regarding frequency, differences were found between PD patients off medication and controls for the action-word category. Discussion: Our data showed a specific deficit in PD patients off medication in categories mainly depending on frontal lobe function (phonological and actions) while these differences were restored with dopamine treatment. Moreover, PD patients off medication produced higher frequency verbs than controls, suggesting that dopamine affects the normal functioning within the lexico-semantic network of verbs.
机译：简介：帕金森氏病（PD）与额叶纹状体网络中的多巴胺消耗有关，这会影响某些语言方面，例如动词处理。一些实验表明，多巴胺缺乏在词汇语义系统的正常功能中起作用。结果，通过检查生成的单词数量和这些单词的使用频率，口语流利度任务可以成为评估语义系统功能的有用工具。目的：本研究的目的是通过口头流利度任务来发现多巴胺如何影响PD患者的表现，重点是行动词的流利度。方法：一组20名PD患者和20名对照参加了研究。评估参与者的口头流利度有四种不同：语音，语义（动物和超市用语）和动作流利度。 PD患者进行了两次测试（开/关药物），并且仅进行了一次对照。结果：就单词数量而言，PD患者在用药和非用药方面的语音和动作流利性任务之间存在显着差异。与对照组相比，停药后的PD在语音和动作方面的用词明显减少。关于频率，发现药物治疗的PD患者与动作词类别的对照之间存在差异。讨论：我们的数据显示，PD患者在停药后存在特定的缺陷，主要取决于额叶功能（语音和动作），而这些差异在多巴胺治疗后得以恢复。此外，停药的PD患者产生的动词频率高于对照组，这表明多巴胺会影响动词词汇-语义网络内的正常功能。

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