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首页> 外文期刊>Egyptian Journal of Basic and Applied Sciences >Interleukin-6 in exhaustive exercises and its correlation to bacteremia: a pilot study
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Interleukin-6 in exhaustive exercises and its correlation to bacteremia: a pilot study

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ABSTRACT Physical activity is important for the prevention of many diseases. However, strenuous physical activity makes individuals more prone to infections. This might be linked to immunosuppression and involves changing in cytokines levels especially IL-6 which act as immunomodulatory agent. The aim of this study is to test the correlation between exercise duration and the level of IL-6 in rats, detect the prevalence of bacteremia in different study groups and find a relation between IL-6 levels, intensity of physical exercises and the susceptibility to infection. Sixteen experimental rats were divided into four groups and have been swimming for different periods of time over three consecutive weeks. Blood samples were obtained at the end of each week before and after the last session of exercise. Blood cultures were done and ELISA for measuring plasma levels of IL-6. IL-6 levels decreased after exercise and this was more significant as the exercise duration increased (R = −0.19, P = 0.05). The more the exercise duration is, the more the susceptibility to infection (R = 0.47, P = 0.01). IL-6 levels in the blood are inversely proportional to the exercise duration which might explain the functional immuno-depression and thus, the increasing susceptibility to infections.

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