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Chemical Exchange Saturation Transfer (CEST) Imaging of pH

机译:pH值的化学交换饱和转移(CEST)成像

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摘要

pH is an important physiological index that alters in a host of disorders including inflammation, ischemic stroke and cancer. Therefore, it is necessary to quickly and accurately detect pH in vivo for diagnosing tissue damage and monitoring its response to treatment. Although magnetic resonance spectroscopy (MRS) can provide non-invasive measurement of pH, its spatiotemporal resolution is somewhat limited, hindering its routine use in clinic. Recently, chemical exchange saturation transfer (CEST) contrast mechanism has been developed as a novel approach to image pH at reasonable spatiotemporal resolution with promising in vivo applications. In this review, we discuss the principles of CEST phenomenon, quantify CEST effect and summarize its in vivo use.
机译:pH是一种重要的生理指标,会在多种疾病(包括炎症,缺血性中风和癌症)中发生变化。因此,有必要在体内快速准确地检测pH以诊断组织损伤并监测其对治疗的反应。尽管磁共振波谱(MRS)可以提供pH值的非侵入式测量,但其时空分辨率受到一定限制,从而妨碍了其在临床中的常规使用。最近,化学交换饱和转移(CEST)对比机制已被开发为一种以合理的时空分辨率对pH值成像的新方法,并有望在体内得到应用。在这篇综述中,我们讨论了CEST现象的原理,量化CEST效果并总结了其在体内的使用。

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