BK virus in kidney transplant recipients with graft dysfunction

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BK virus in kidney transplant recipients with graft dysfunction

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ABSTRACT This study was to estimate the viral load of BK virus (BKV) in the urine and blood of Kidney transplant recipients (KTRs) with graft dysfunction and its effect on the development of graft dysfunction. This analysis included all KTR outpatients who visited the clinic at Urology and Nephrology Center during their routine follow-up visits from September 2017 to May 2019. A total of 100 patients were divided into 62 KTR patients with kidney dysfunction (case group) vs. 38 KTR patients without kidney dysfunction (control group). BKV DNA quantification in urine and plasma samples was examined in all patients by the real time PCR method. The BKV DNA was detected in the urine samples of 5 patients, all with kidney dysfunction (8) vs. none in the control group. The BKV viral load of the 5 cases ranged from 105 to 244000 copies/ml. The BKV DNA was not detected in the blood samples of the 5 urine-positive cases. It was concluded that all patients with kidney dysfunction should be screened for BKV in their urine samples to prevent the development of BKV-caused nephropathy and further graft failure.

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《Egyptian Journal of Basic and Applied Sciences》 |2023年第1期|195-203|共9页
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Mansoura University;

Mansoura University;

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正文语种英语
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BK virus; BK virus nephropathy; kidney transplant recipient; Nephropathy; renal transplantation;

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机译：Successful treatment of BK virus associated-nephropathy in a human immunodeficiency virus-positive kidney transplant recipient
2. Challenging Issues in Diagnosis and Screening of BK Virus Nephropathy in Kidney Transplant Recipients, A Multicenter Experience in Iranian Population [J] . Nili Fatemeh, Khatami Seyed Mohammadreza, Saberafsharian MaliheShahsiah RezaShakiba YadollahSeirafi GolnarSadeghi YasamanMiri MaryamAtaei RezaMohamadhoseini Malihe iranian journal of kidney diseases . 2022,第6期

机译：Challenging Issues in Diagnosis and Screening of BK Virus Nephropathy in Kidney Transplant Recipients, A Multicenter Experience in Iranian Population
3. Mass in nonfunctioning first renal allograft in a recipient of 2 transplant kidneys -BK polyoma virus-associated pelvic high-grade urothelial carcinoma [J] . Kidney international. . 2019,第4期

机译：Mass in nonfunctioning first renal allograft in a recipient of 2 transplant kidneys -BK polyoma virus-associated pelvic high-grade urothelial carcinoma
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BK virus in kidney transplant recipients with graft dysfunction

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