...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Egyptian Journal of Basic and Applied Sciences >Investigate the role of PIK3CA gene expression in colorectal polyp development
【24h】

Investigate the role of PIK3CA gene expression in colorectal polyp development

机译：

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

ABSTRACT Background Polyps are pathological concerning histological changes that develop during colorectal and rectal cancer. The degree of polyp severity is due to their ability to transform the polyp cells from normal to malignant. PIK3CA is a gene that plays an important role in cell cycle regulation.Objective The study aims to evaluate PIK3CA gene expression in tissues of colorectal polyps.Methods Two study groups employed in the current study were patients (n = 68) and the control group (n = 50). Immunohistochemical techniques were applied to paraffin-embedded tissues to localize PIK3CA expression.Results The current study showed a significant difference between the control and patients group in PIK staining results; in the control group, there was no case positive for PIK, while in the patient group, all cases were positive. In the rectum, there was no significant difference between cases given positive and negative. Among histological types, according to tubular adenoma histological type, in the right colon, the cases which gave positive for PIK were significantly lower than negative, while in the left colon, the cases which gave positive were significantly higher than negative.Conclusion The PIK3CA gene initiates polyp formation and benign tumoral growths, which may subsequently undergo malignant transformation.

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号