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首页> 外文期刊>Materials science & engineering, C. Materials for Biogical applications >Biocomposite scaffolds based on electrospun poly(3-hydroxybutyrate) nanofibers and electrosprayed hydroxyapatite nanoparticles for bone tissue engineering applications
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Biocomposite scaffolds based on electrospun poly(3-hydroxybutyrate) nanofibers and electrosprayed hydroxyapatite nanoparticles for bone tissue engineering applications

机译：基于电纺聚（3-羟基丁酸）纳米纤维和电喷涂羟基磷灰石纳米粒子的生物复合支架，用于骨组织工程应用

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摘要

The electrospinning technique combinedwith the electrospraying process provides a straightforward and versatile approach for the fabrication of novel nanofibrous biocomposite scaffolds with structural, mechanical, and biological properties potentially suitable for bone tissue regeneration. In this comparative investigation, three types of poly(3-hydroxybutyrate) (PHB)-based scaffolds were engineered: (i) PHB mats by electrospinning of a PHB solution, (ii) mats of PHB/hydroxyapatite nanoparticle (nHA) blends by electrospinning of a mixed solution containing PHB and nHAs, and (iii) mats constituted of PHB nanofibers and nHAs by simultaneous electrospinning of a PHB solution and electrospraying of a nHA dispersion. Scaffolds based on PHBHA blends displayed improved mechanical properties compared to those of neat PHB mats, due to the incorporation of nHAs within the fibers. The electrospinning/electrospraying approach afforded biocomposite scaffolds with lower mechanical properties, due to their higher porosity, but they displayed slightly better biological properties. In the latter case, the bioceramic, i.e. nHAs, largely covered the fiber surface, thus allowing for a direct exposure to cells. The 21 daymonitoring through the use of MTS assays and SEM analyses demonstrated that human mesenchymal stromal cells (hMSCs) remained viable on PHBHA biocomposite scaffolds and proliferated continuously until reaching confluence.
机译：静电纺丝技术与电喷涂工艺相结合，为制造新型纳米纤维生物复合材料支架提供了一种直接而通用的方法，该支架具有可能适合骨骼组织再生的结构，机械和生物学特性。在此比较研究中，设计了三种类型的基于聚（3-羟基丁酸酯）（PHB）的支架：（i）通过电纺PHB溶液的PHB垫子;（ii）通过电纺PHB /羟基磷灰石纳米颗粒（nHA）混合物的垫子通过同时电纺PHB溶液和电喷雾nHA分散体来制备包含PHB和nHA的混合溶液，以及（iii）由PHB纳米纤维和nHA构成的垫。与纯PHB毡相比，基于PHB / nHA共混物的支架表现出改善的机械性能，这是由于nHA在纤维中的结合。由于其较高的孔隙率，电纺/电喷雾方法使生物复合材料支架的机械性能较低，但它们的生物学性能稍好。在后一种情况下，生物陶瓷，即nHAs，在很大程度上覆盖了纤维表面，因此可以直接暴露于细胞中。通过使用MTS分析和SEM分析进行的21天监测表明，人间充质基质细胞（hMSCs）在PHB / nHA生物复合支架上仍保持活力，并持续增殖直至融合。

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