Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination

Chi Xiangyang; Guo Yingying; Zhang GuanyingSun HancongZhang JunLi MinChen ZhengshanHan JinZhang YuanyuanZhang XinghaiFan PengfeiZhang ZheWang BusenZai XiaodongHan XuelianHao MengFang TingXu JinghanWu ShipoChen YiFang YingyingDong YunzhuSun BingjieZhang JinlongLi JianminZhao GuangyuYu ChangmingZhou QiangChen Wei

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Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination

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The SARS-CoV-2 Omicron variant shows substantial resistance to neutralization by infection- and vaccination-induced antibodies, highlighting the demands for research on the continuing discovery of broadly neutralizing antibodies (bnAbs). Here, we developed a panel of bnAbs against Omicron and other variants of concern (VOCs) elicited by vaccination of adenovirus-vectored COVID-19 vaccine (Ad5-nCoV). We also investigated the human longitudinal antibody responses following vaccination and demonstrated how the bnAbs evolved over time. A monoclonal antibody (mAb), named ZWD12, exhibited potent and broad neutralization against SARS-CoV-2 variants Alpha, Beta, Gamma, Kappa, Delta, and Omicron by blocking the spike protein binding to the angiotensin-converting enzyme 2 (ACE2) and provided complete protection in the challenged prophylactic and therapeutic K18-hACE2 transgenic mouse model. We defined the ZWD12 epitope by determining its structure in complex with the spike (S) protein via cryo-electron microscopy. This study affords the potential to develop broadly therapeutic mAb drugs and suggests that the RBD epitope bound by ZWD12 is a rational target for the design of a broad spectrum of vaccines.

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《signal transduction and targeted therapy》 |2022年第1期|共11页
作者
Chi Xiangyang; Guo Yingying; Zhang GuanyingSun HancongZhang JunLi MinChen ZhengshanHan JinZhang YuanyuanZhang XinghaiFan PengfeiZhang ZheWang BusenZai XiaodongHan XuelianHao MengFang TingXu JinghanWu ShipoChen YiFang YingyingDong YunzhuSun BingjieZhang JinlongLi JianminZhao GuangyuYu ChangmingZhou QiangChen Wei;
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Acad Mil Med Sci;

Westlake Univ;

Acad Mil Med SciChinese Acad Sci;

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1. Neutralizing Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants Induced by Natural Infection or Vaccination: A Systematic Review and Pooled Analysis [J] . XinhuaChen, ZhiyuanChen, Andrew SAzmanRuijiaSunWanyingLuNanZhengJiaxinZhouQianhuiWuXiaoweiDengZeyaoZhaoXinghuiChenShijiaGeJuanYangDaniel TLeungHongjieYu Clinical infectious diseases . 2022,第4期

机译：Neutralizing Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants Induced by Natural Infection or Vaccination: A Systematic Review and Pooled Analysis
2. Evaluation of Neutralizing Antibodies against SARS-CoV-2 Variants after Infection and Vaccination Using a Multiplexed Surrogate Virus Neutralization Test [J] . Lynch Kara L., Zhou Shuxia, Kaul RaviWalker RogerWu Alan H. Clinical Chemistry: Journal of the American Association for Clinical Chemists . 2022,第5期

机译：Evaluation of Neutralizing Antibodies against SARS-CoV-2 Variants after Infection and Vaccination Using a Multiplexed Surrogate Virus Neutralization Test
3. Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer [J] . Zhan Wuqiang, Tian Xiaolong, Zhang XiangXing ShenghuiSong WenpingLiu QianyingHao AihuaHu YuxiaZhang MengYing TianleiChen ZhenguoLan FeiSun Lei Journal of Virology . 2022,第16期

机译：Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer
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Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination

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