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The dynamics of three-dimensional chromatin organization and phase separation in cell fate transitions and diseases

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摘要

© 2022, The Author(s).Cell fate transition is a fascinating process involving complex dynamics of three-dimensional (3D) chromatin organization and phase separation, which play an essential role in cell fate decision by regulating gene expression. Phase separation is increasingly being considered a driving force of chromatin folding. In this review, we have summarized the dynamic features of 3D chromatin and phase separation during physiological and pathological cell fate transitions and systematically analyzed recent evidence of phase separation facilitating the chromatin structure. In addition, we discuss current advances in understanding how phase separation contributes to physical and functional enhancer-promoter contacts. We highlight the functional roles of 3D chromatin organization and phase separation in cell fate transitions, and more explorations are required to study the regulatory relationship between 3D chromatin organization and phase separation. Graphical Abstract: 3D chromatin organization (shown by Hi-C contact map) and phase separation are highly dynamic and play functional roles during early embryonic development, cell differentiation, somatic reprogramming, cell transdifferentiation and pathogenetic process. Phase separation can regulate 3D chromatin organization directly, but whether 3D chromatin organization regulates phase separation remains unclear.Figure not available: see fulltext.

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  • 来源
    《cell regeneration》 |2022年第1期|共页
  • 作者

    Ling X.; Liu X.; Jiang S.Fan L.Ding J.;

  • 作者单位

    Advanced Medical Technology Center The First Affiliated Hospital Zhongshan School of Medicine Sun Yat-Sen University;

    RNA Biomedical Institute Sun Yat-Sen Memorial Hospital Zhongshan School of Medicine Sun Yat-Sen University;

    Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue Engineering Ministry of Education Zhongshan School of Medicine Sun Yat-Sen UniversityGuangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine School of Traditional Chinese Medicine Jinan UniversityDepartment of Histology and Embryology School of Basic Medical Sciences Guangzhou Medical UniversityWest China Biomedical Big Data Center West China Hospital Sichuan University;

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  • 正文语种 英语
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  • 关键词

    3D chromatin organization; Cell fate transitions; Disease; Phase separation;

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