Detection of an influenza B virus strain with reduced susceptibility to neuraminidase inhibitor drugs.

Bastien N; Gubbay JB; Richardson DSleeman KGubareva LLi Y

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Detection of an influenza B virus strain with reduced susceptibility to neuraminidase inhibitor drugs.

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The neuraminidase inhibitors (NAIs) oseltamivir and zana-mivir have played an essential role in the prophylaxis and treatment of influenza. The residues forming the NA active sites are conserved among influenza A and B viruses (3). Conserved residues are in direct contact with the substrate or provide structural framework for the functional residues. There have been reports of in vivo resistance for influenza B viruses (4, 7). Here we report the isolation of a novel influenza B virus with reduced sensitivity to NAIs.

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《Journal of Clinical Microbiology》 |2011年第11期|4020-4021|共2页
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Bastien N; Gubbay JB; Richardson DSleeman KGubareva LLi Y;
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正文语种英语
中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. A Computational Model for Docking of Noncompetitive Neuraminidase Inhibitors and Probing their Binding Interactions with Neuraminidase of Influenza Virus H5N1 [J] . Chintakrindi Anand S., Martis Elvis A. F., Gohil Devanshi J.Kothari Sweta T.Chowdhary Abhay S.Coutinho Evans C.Kanyalkar Meena A. Current computer-aided drug design . 2016,第4期

机译：A Computational Model for Docking of Noncompetitive Neuraminidase Inhibitors and Probing their Binding Interactions with Neuraminidase of Influenza Virus H5N1
2. Assessment of population susceptibility to upcoming seasonal influenza epidemic strain using interepidemic emerging influenza virus strains [J] . Chen Lin-Lei, Wu Wai-Lan, Chan Wan-MuiFong Carol H. Y.Ng Anthony C. K.Ip Jonathan D.Lu LuDissanayake Thrimendra K.Ding XixiaCai Jian-PiaoZhang Anna J. X.Tam SidneyHung Ivan F. N.Chan Kwok-HungYuen Kwok-YungTo Kelvin K. W. Epidemiology and infection. . 2019,第1期

机译：Assessment of population susceptibility to upcoming seasonal influenza epidemic strain using interepidemic emerging influenza virus strains
3. In Vitro Profiling of Laninamivir-Resistant Substitutions in N3 to N9 Avian Influenza Virus Neuraminidase Subtypes and Their Association with In Vivo Susceptibility (vol 95, e01679-20, 2020) [J] . Jeong Ju Hwan, Choi Won-Suk, Antigua Khristine Joy C.Choi Young KiGovorkova Elena A.Webby Richard J.Baek Yun HeeSong Min-Suk Journal of Virology . 2021,第6期

机译：In Vitro Profiling of Laninamivir-Resistant Substitutions in N3 to N9 Avian Influenza Virus Neuraminidase Subtypes and Their Association with In Vivo Susceptibility (vol 95, e01679-20, 2020)
4. Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer [O] . Yamada, Tadaaki, Matsumoto, Kunio, Wang, Wei, 2010

机译：Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790m mutant lung cancer

Detection of an influenza B virus strain with reduced susceptibility to neuraminidase inhibitor drugs.

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