Mending a broken heart with novel cardiogenic small molecules

Powers N.; Huang G.N.

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Mending a broken heart with novel cardiogenic small molecules

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© 2022, The Author(s).Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and cytokinesis. The authors generate a cocktail of five small molecules that increase cardiomyocyte proliferation and regeneration in vitro and in vivo with high efficiency, and explore its potential in cardiac regenerative repair after myocardial infarction through a new potential pathway for cardiomyocyte cell-cycle re-entry.

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《cell regeneration》 |2022年第1期|共页
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Powers N.; Huang G.N.;
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Cardiovascular Research Institute & Department of Physiology University of California San Francisco;

Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research University of California San Francisco;

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Mending a broken heart with novel cardiogenic small molecules

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