Stephanoascus ciferrii is an ascomycetous yeast-like fungus, rarely causing human infections. It is also a teleomorph of Candida ciferrii. This species has a strong tendency to become resistant especially in patients on fluconazole prophylaxis. We report a case of post-mastoidectomy with continuous aural discharge not responding to topical and systemic treatment. Further characterisation showed ascospore formation and fluconazole resistance. Therefore, in vitro susceptibility testing is mandatory for the selection of appropriate antifungal drugs. This case report will alert the clinicians to look for fluconazole resistant yeast causing highly resistant aural infections.
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