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首页> 外文期刊>Cell metabolism >Palatability Can Drive Feeding Independent of AgRP Neurons
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Palatability Can Drive Feeding Independent of AgRP Neurons

机译：适口性可以独立于AgRP神经元来驱动进食

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Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense foods and the consequent obesity epidemic. Hypothalamic agouti-related peptide-secreting neurons (AgRP neurons) provide the primary orexigenic drive of homeostatic feeding. Using models of neuronal inhibition or ablation, we demonstrate that the feeding response to a fast ghrelin or serotonin receptor agonist relies on AgRP neurons. However, when palatable food is provided, AgRP neurons are dispensable for an appropriate feeding response. In addition, AgRP-ablated mice present exacerbated stress-induced anorexia and palatable food intake-a hallmark of comfort feeding. These results suggest that, when AgRP neuron activity is impaired, neural circuits sensitive to emotion and stress are engaged and modulated by food palatability and dopamine signaling.
机译：稳定的和享乐的神经底物很好地调节了进食行为，这些底物整合了能量需求以及食物的强化和有益成分。由于无处不在的能量密集食品的来源以及随之而来的肥胖病流行，了解稳态和奖励驱动的喂养的净贡献已变得至关重要。下丘脑刺痛相关肽分泌神经元（AgRP神经元）提供稳态喂养的主要致癌驱动。使用神经元抑制或消融模型，我们证明对快速生长素释放肽或5-羟色胺受体激动剂的摄食反应依赖于AgRP神经元。但是，当提供可口的食物时，AgRP神经元对于适当的进食反应是必不可少的。此外，AgRP消融的小鼠表现出加剧的应激诱导的厌食症和可口的食物摄入-舒适喂养的标志。这些结果表明，当AgRP神经元活性受损时，对食物和适口性和多巴胺信号传导的情绪和压力敏感的神经回路就会参与和调节。

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