Treponema-specific tests for serodiagnosis of syphilis: comparative evaluation of seven assays.

Binnicker MJ; Jespersen DJ; Rollins LO

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Treponema-specific tests for serodiagnosis of syphilis: comparative evaluation of seven assays.

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The diagnosis of syphilis is challenging and often relies on serologic tests to detect treponemal or nontreponemal antibodies. Recently, the Centers for Disease Control and Prevention and the Association of Public Health Laboratories proposed an update to the syphilis serology testing algorithm, in which serum samples are first tested using a treponema-specific test and positive samples are analyzed with a nontreponemal assay. The goal of this study was to compare the performance of seven treponemal assays (BioPlex 2200 syphilis IgG Bio-Rad, Hercules, CA, fluorescent treponemal antibody FTA assay Zeus Scientific, Raritan, NJ, Treponema pallidum particle agglutination TP-PA; Fujirebio Diagnostics, Malvern, PA, Trep-Sure enzyme immunoassay EIA; Phoenix Biotech, Oakville, Ontario, Canada, Trep-Chek EIA Phoenix Biotech, Trep-ID EIA Phoenix Biotech, and Treponema ViraBlot IgG Viramed Biotech AG, Planegg, Germany) using serum samples (n = 303) submitted to our reference laboratory. In addition to testing with these 7 assays, all samples were tested by a rapid plasma reagin (RPR) assay and a treponemal IgM Western blot assay (Viramed ViraBlot). Compared to the FTA assay as the gold standard, the evaluated treponemal tests demonstrated comparable levels of performance, with percent agreement ranging from 95.4 (95 confidence interval, 92.3 to 97.3) for the Trep-Sure EIA to 98.4 (96.1 to 99.4) for the Trep-ID EIA. Compared to a "consensus of the test panel" (defined as at least 4 of 7 treponemal tests being in agreement), the percent agreement ranged from 95.7 (92.7 to 97.5) for Trep-Sure to 99.3 (97.5 to 99.9) for Trep-ID. These data may assist clinical laboratories that are considering implementing a treponemal test for screening or confirmatory purposes.

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《Journal of Clinical Microbiology》 |2011年第4期|1313-1317|共5页
作者
Binnicker MJ; Jespersen DJ; Rollins LO;
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Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.;

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正文语种英语
中图分类医学微生物学（病原细菌学、病原微生物学）;
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Treponema-specific tests for serodiagnosis of syphilis: comparative evaluation of seven assays.

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