WCN23-1109 EFFECT OF MULTIDRUG RESISTANCE-1 (MDR1) C3435T GENETIC POLYMORPHISM ON DETERMINATION OF TACROLIMUS DOSING AND TOXICITY IN RENAL TRANSPLANT RECIPIENTS

M. Aung Hein; K. Phyu Pyar; K. Maung Maung ThanS. Aik HlaW. Kyaw ShweY. Htook MaungH. LynnK. Thuyein LwinC. Pyae AungL. Maung MaungL. Htet AungY. Min HeinM. Tun ZawM. Maung Maung

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WCN23-1109 EFFECT OF MULTIDRUG RESISTANCE-1 (MDR1) C3435T GENETIC POLYMORPHISM ON DETERMINATION OF TACROLIMUS DOSING AND TOXICITY IN RENAL TRANSPLANT RECIPIENTS

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Tacrolimus remains the cornerstone of renal transplant immunosuppressive regimen since many decades. The toxicity with narrow therapeutic widow and significant intra and inter individual variations in pharmacokinetics (PK) and pharmacodynamics (PD) of tacrolimus are the main obstacles in the clinical use of this drug. Evidences are emerging which show that genetic polymorphisms can influence PK and PD of tacrolimus. In this study the effect of MDR1 C3435T SNP on tacrolimus dosing and toxicities was extensively considered in renal transplant recipients for the first 3 months of post renal transplantation.

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《asian journal of surgery》 |2023年第3期|413-413|共1页
作者
M. Aung Hein; K. Phyu Pyar; K. Maung Maung ThanS. Aik HlaW. Kyaw ShweY. Htook MaungH. LynnK. Thuyein LwinC. Pyae AungL. Maung MaungL. Htet AungY. Min HeinM. Tun ZawM. Maung Maung;
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Defence Services Medical Academy,Department of Medicine and Nephrology;

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机译：Association Between CYP3A5 Genetic Polymorphisms with Tacrolimus Dose Requirement and Allograft Outcomes in Iranian Kidney Transplant Recipients

WCN23-1109 EFFECT OF MULTIDRUG RESISTANCE-1 (MDR1) C3435T GENETIC POLYMORPHISM ON DETERMINATION OF TACROLIMUS DOSING AND TOXICITY IN RENAL TRANSPLANT RECIPIENTS

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