Synthesis and antitumor activity of some new pyrazolo3,4-dpyrimidine and pyrazolo3,4-bpyridine derivatives

E. Abdel-latif; S. Abdel-fattah; H.E. GafferH.A. Etman

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Synthesis and antitumor activity of some new pyrazolo3,4-dpyrimidine and pyrazolo3,4-bpyridine derivatives

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摘要

A new series of pyrazolo3,4-dpyrimidine-3-carbonitrile and pyrazolo3,4-bpyridine-3-carbonitrile derivatives was synthesized by the reaction of 5-amino-1-tosyl-1H-pyrazole-3,4-dicarbonitrile as a key starting material with various electrophilic and nucleophilic reagents. All the newly synthesized compounds were structurally confirmed by various modern analytical methods (IR,1H NMR and MS). All the title compounds have been evaluated for their potential cytotoxicity against human laryngeal epidermoid carcinoma cells(Hep2). Among the screened compounds,3and4exhibited the highest significant effect.

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来源
《Egyptian Journal of Basic and Applied Sciences》 |2016年第1期|118-124|共7页
作者
E. Abdel-latif; S. Abdel-fattah; H.E. GafferH.A. Etman;
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作者单位

Department of Chemistry, Faculty of Science, Mansoura University;

Textile Research Division, National Research Centre;

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正文语种英语
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5-Aminopyrazole; Phenyl isothiocyanate; Formic acid; Thiourea; Pyrazolo3,4-dpyrimidines; Antitumor activity; Epidermoid carcinoma;

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机译：Michael Cyclization of Polarized Systems: Synthesis and in vitro Anti-Diabetic Evaluation of Some Novel Pyrimidine, Pyridine, Pyrazole and Pyrazolo3,4-b pyridine Derivatives
2. ChemInform Abstract: Synthesis of Some New Pyrazolo(4,3‐b)pyridine, Pyridine, Pyrazolo(1,5‐ a)pyrimidine and Thiazole Derivatives. [J] . F. M. A. EL‐TAWEEL Chem Inform . 1996,第4期

机译：ChemInform Abstract: Synthesis of Some New Pyrazolo(4,3‐b)pyridine, Pyridine, Pyrazolo(1,5‐ a)pyrimidine and Thiazole Derivatives.
3. ChemInform Abstract: Synthesis of Pyrazolo(3,4‐d)pyridazine, Pyrazolo(3,4‐d)pyrimidine, and Imidazo(1,2‐a)pyridine Derivatives Using Hydrazonyl Bromides. [J] . H. M. HASSANEEN, A. S. SHAWALI, N. M. ELWANN. M. ABOUNADA Chem Inform . 1992,第36期

机译：ChemInform Abstract: Synthesis of Pyrazolo(3,4‐d)pyridazine, Pyrazolo(3,4‐d)pyrimidine, and Imidazo(1,2‐a)pyridine Derivatives Using Hydrazonyl Bromides.
4. Synthesis of monomethylated dioscin derivatives and their antitumor activities [O] . Li M, Han XW, Yu B 2003

机译：synthesis of monomethylated dioscin derivatives and their antitumor activities

Synthesis and antitumor activity of some new pyrazolo3,4-dpyrimidine and pyrazolo3,4-bpyridine derivatives

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