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首页> 外文期刊>Laboratory Animal Science >Anthelmintic treatment to eradicate cutaneous capillariasis in a colony of South African clawed frogs (Xenopus laevis).
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Anthelmintic treatment to eradicate cutaneous capillariasis in a colony of South African clawed frogs (Xenopus laevis).

机译：驱虫治疗以根除南非爪蛙（Xenopus laevis）菌落中的皮肤毛细血管病。

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Capillaria xenopodis is a skin parasite of Xenopus laevis and is quite common in laboratory animal facilities where it causes serious skin changes and may lead to wasting and death of affected frogs. The anthelmintics ivermectin and levamisole weresuccessively tested for practicability of elimination of the parasite from a colony of clawed frogs in Germany. Nematodes were reduced below diagnostic levels by various methods of application of ivermectin (orally or by injection into the dorsal lymph sac, twice at intervals of 10 to 14 days) but recurred again in treated animals 1 to 3 months later. Treatment using ivermectin-medicated tank water was not feasible due to the low water solubility of the drug. Elimination of the parasite was reliably achieved using levamisole-medicated tank water and relapses did not occur during the 18-month post-treatment period. Levamisole concentration was 12 mg/litre, with 4.17, 5.00 or 6.25 litres of tank water/frog, and 50, 60 or 75 mg of levamisole available/frog for at least 4 days, with treatments repeated after 10 to 14 days. Results were reproducible in 2 trials each with 5 tanks containing 4 or 5 frogs each. A trial carried out with a group of 20 adult frogs exposed to 12 mg of levamisole/litre but with only 2.5 litres of tank water/frog and 30 mg of levamisole available/frog, was not effective. Both drug concentration and the amount of drug available per frog appear to be important. No adverse effects were seen with levamisole as have been reported withthiabendazole.
机译：毛细血管毛虫是非洲爪蟾的皮肤寄生虫，在实验室动物设施中很常见，会引起严重的皮肤变化，并可能导致蛙类的浪费和死亡。对驱虫药伊维菌素和左旋咪唑成功地进行了测试，以从德国的有爪蛙群落中清除寄生虫。通过使用伊维菌素的各种方法（口服或通过注射到背侧淋巴囊中，每隔10到14天两次）将线虫降低到诊断水平以下，但在1-3个月后再次在治疗的动物中复发。由于伊维菌素加药的罐装水的水溶性低，因此不可行。使用左旋咪唑治疗的储水箱可以可靠地消除寄生虫，并且在治疗后的18个月内没有复发。左旋咪唑的浓度为12 mg / L，每桶可用4.17、5.00或6.25升水/青蛙，以及50/60或75 mg左旋咪唑/青蛙可用，持续至少4天，并在10至14天后重复进行处理。结果在2个试验中均具有可重复性，每个试验有5个水箱，每个水箱包含4个或5个青蛙。对一组20只成年青蛙暴露于12 mg左旋咪唑/升但仅储有2.5升储水/青蛙和30 mg左旋咪唑/青蛙的试验无效。每只青蛙的药物浓度和可用药物量似乎都很重要。如噻苯达唑报道的，左旋咪唑未见不良反应。

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