Ventricular pressure and dimension measurements in mice

Michael I. Miyamoto; Catherine S. Kim; J. Luis Guerrero

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Ventricular pressure and dimension measurements in mice

机译：小鼠心室压力和尺寸的测量

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The recent development of techniques for assessment of cardiac physiology in genetically engineered mice has allowed scientists to address some of the most fundamental questions related to congenital and acquired forms of human heart disease. It is possible to reliably examine murine cardiac physiology in vivo by use of microtransducers, echocardiography, and other miniaturized techniques (1-3). Sophisticated methods have also been developed to enable examination of single-cell phenotypes of isolated cardiomyocytes derived from genetically engineered mice. These physiologic assessments, coupled with conventional histologic examination and molecular markers, have allowed the characterization of several gene-targeted and transgenic mouse models of hypertrophy and dilated cardiomyopathy, as well as mouse models of cardiac developmental defects. Such mouse models of heart disease may ultimately allow the molecular dissection of the interplay between the various factors leading to heart disease, and they may serve as a guide to appropriate therapeutic strategies for human heart disease. To further study the dynamics of volume changes in the left ventricle (LV) and to obtain load-independent parameters of LV contractility, we have developed a method of measuring ventricular dimensions in the open thorax mouse.

机译：基因工程小鼠心脏生理评估技术的最新发展使科学家能够解决与先天性和获得性人类心脏病有关的一些最基本的问题。通过使用微换能器，超声心动图和其他小型化技术，可以在体内可靠地检查鼠的心脏生理学（1-3）。还已经开发出复杂的方法来检查源自基因工程小鼠的分离的心肌细胞的单细胞表型。这些生理评估，再加上常规的组织学检查和分子标记，已经可以鉴定出肥大和扩张型心肌病的几种以基因为靶标和转基因的小鼠模型，以及心脏发育缺陷的小鼠模型。此类心脏病小鼠模型最终可能会导致导致心脏病的各种因素之间相互作用的分子解剖，并且它们可作为指导人类心脏病的适当治疗策略的指南。为了进一步研究左心室（LV）体积变化的动力学并获得与负荷无关的LV收缩力参数，我们开发了一种测量开胸小鼠心室尺寸的方法。

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《Laboratory Animal Science》 |1999年第3期|共3页
作者
Michael I. Miyamoto; Catherine S. Kim; J. Luis Guerrero;
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中图分类动物学实验（实验动物学）、动物学技术;
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1. Ventricular Pressure and Dimension Measurements in Mice [J] . Comparative Medicine . 1999,第3期

机译：小鼠的心室压力和尺寸测量
2. Left ventricular pressure-volume measurements in mice: Comparison of closed-chest versus open-chest approach. [J] . Lips DJ, V D Nagel T, Steendijk P, Basic Research in Cardiology: Official Journal of the German Association of Cardiovascular Research . 2004,第5期

机译：小鼠左心室压力-容积测量：封闭式胸腔法与开放式胸腔法的比较。
3. Simultaneous LV pressure-volume measurement in mice with MRI and ventricular catheterization [J] . A Wansapura, RS Dunn, J Wansapura Journal of cardiovascular magnetic resonance : . 2013,第Suppla1期

机译：MRI和心室导管检查同时测量左室压力
4. Computerized system for the assessment of left ventricular function based on ventricular dimensions and intracardiac pressure measurements [C] . Hnatkova, K., Varma, . 1999

机译：基于心室尺寸和心内压测量的评估左心室功能的计算机系统
5. Modeling and Measurement of Pressure Overload-Induced Changes in Left Ventricular Structure and Function [D] . Farrar, Genevieve E. 2014

机译：压力超负荷导致左心室结构和功能变化的建模和测量
6. Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice [O] . Wen-Chi Chen, Sung-Hyun Park, Carol Hoffman, 2013

机译：右心室收缩压测量与小鼠肺和免疫组织样本的采集相结合
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Ventricular pressure and dimension measurements in mice

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