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首页> 外文期刊>Laboratory Animal Science >Five spontaneous deaths associated with Clostridium difficile in a colony of cotton-top tamarins (Saguinus oedipus).
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Five spontaneous deaths associated with Clostridium difficile in a colony of cotton-top tamarins (Saguinus oedipus).

机译：在棉顶猴（Saguinus oedipus）菌落中，有五例与艰难梭菌相关的自然死亡。

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摘要

C. difficile toxin was detected in the faeces of 5 cotton-top tamarins (Saguinus oedipus) that died spontaneously over a period of 10 weeks. Deaths occurred subsequent to antibiotic therapy for infectious diarrhoea associated with Campylobacter spp.Clinical signs before death included weight loss, watery diarrhoea, haematochezia, weakness, and sudden collapse. Histological examination of the colon identified pseudomembranous colitis in 2 cases, a lesion consistent with C. difficile lesions in man.This finding prompted submission of faeces for C. difficile toxin analysis from these 5 cases. Four of the tamarins were from a single room, and the fifth was housed nearby. The proximity of the cases raises the possibility of environmental contamination by resistant C. difficile spores or faecal spread of the organism as reported in hospitals, day-care centres, and nurseries. The relative importance of C. difficile and its potential role as an unrecognized cause of enteric disease secondary to antibiotic therapy in nonhuman primates is discussed.
机译：在5个棉顶猴（Saguinus oedipus）的粪便中检测到艰难梭菌毒素，它们在10周内自发死亡。抗生素治疗因弯曲杆菌引起的感染性腹泻而死亡。死亡前的临床体征包括体重减轻，水样腹泻，血尿，虚弱和突然虚脱。结肠的组织学检查发现2例假膜性结肠炎，其病变与人的艰难梭菌病变一致，这一发现促使这5例患者进行了艰难梭菌毒素分析的粪便。其中的四只绢毛猴来自一间单人房，而另一只则位于附近。如医院，日托中心和托儿所所报道的那样，病例的临近增加了耐药性艰难梭菌孢子或生物的粪便传播对环境造成污染的可能性。讨论了艰难梭菌的相对重要性及其在非人类灵长类动物中作为抗生素治疗继发于肠道疾病的未被认识的病因的潜在作用。

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