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首页> 外文期刊>Laboratory Animal Science >Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in hairless descendants of Mexican hairless dogs (Xoloitzcuintli)
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Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in hairless descendants of Mexican hairless dogs (Xoloitzcuintli)

机译：对苯二酚治疗墨西哥无毛犬无毛后代皮肤色素沉着的功效（Xoloitzcuintli）

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摘要

Spotty pigmentation in the skin of adult hairless dogs was treated by administration of the depigmenting agent (3% hydroquinone, HQ) for 1 month. Depigmenting effects were examined by use of 3 methods: skin colour, dihydroxyphenylalanine (DOPA)-positive melanocyte count and histological evaluation. The treated skin of hairless dogs began to become depigmented after application of HQ for 1 week. After 1 month of treatment with HQ, depigmentation spread over a quarter of the body. The number of DOPA-positive melanocytes in the HQ-treated sites decreased to less than approximately a fifth of that before treatment. In HQ-treated skin, histological staining by use of Fontana-Masson's method revealed complete absence of melanin pigment. It is concludedthat hairless dogs should be a useful animal model for investigating the effects and cutaneous toxicity of depigmenting agents.
机译：通过施用脱色剂（3％对苯二酚，HQ）治疗1个月，可以治疗成年无毛犬皮肤上的斑点色素沉着。使用三种方法检查色素脱色效果：肤色，二羟基苯丙氨酸（DOPA）阳性黑素细胞计数和组织学评估。应用HQ 1周后，无毛狗的治疗皮肤开始脱色。用HQ治疗1个月后，色素沉着扩散到身体的四分之一处。 HQ治疗部位的DOPA阳性黑色素细胞数量减少到少于治疗前的五分之一。在HQ处理过的皮肤中，使用Fontana-Masson方法进行的组织学染色显示完全没有黑色素色素。结论是，无毛犬应该是研究脱色剂的作用和皮肤毒性的有用动物模型。

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