Synthesis, characterization and antimalarial screening of some new N-(2-chloroquinolin-3-yl)methylenebenzenamines

Yogesh Murti; Sujeet K. Gupta  Devender Pathak

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Synthesis, characterization and antimalarial screening of some new N-(2-chloroquinolin-3-yl)methylenebenzenamines

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A convenient synthesis of N-(2-chloroquinolin-3-yl)methylenebenzenamines (1-12) (Schiffrsquo;s bases), is achieved in two steps. Acetanilide on reaction Vilsmeier-Haack reagent give 2-chloro- 3-formyl quinoline followed by reaction with different substituted aryl amines. All the compounds have been characterized by their melting point, elemental analysis, IR, 1H NMR amp; MASS spectra. The synthesized compounds have been screened for antimalarial activity.

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《Der Pharma Chemica》 |2010年第4期|271-277|共7页
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Yogesh Murti; Sujeet K. Gupta Devender Pathak;
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Synthesis, characterization and antimalarial screening of some new N-(2-chloroquinolin-3-yl)methylenebenzenamines

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