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首页> 外文期刊>Techniques in coloproctology. >Deep remission improves the quality of life of patients with Crohn’s disease and anoperineal fistula treated with darvadstrocel: results of a French pilot study
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Deep remission improves the quality of life of patients with Crohn’s disease and anoperineal fistula treated with darvadstrocel: results of a French pilot study

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Abstract Background The injection of allogeneic adipose tissue-derived mesenchymal stem cells (MSC) into anal fistulas in patients with Crohn’s disease has never been evaluated in “real-life” conditions in France.Methods We prospectively studied the first patients receiving MSC injections at our center and undergoing 12?months of follow-up. The primary endpoint was the clinical and radiological response rate. The secondary endpoints were symptomatic efficacy, safety, anal continence, quality of life (Crohn’s anal fistula-quality of life scale, CAF-QoL), and predictive factors of success.Results We included 27 consecutive patients. The complete clinical and radiological response rates at M12 were 51.9 and 50, respectively. The combined complete clinical–radiological response (deep remission) rate was 34.6. No major adverse effects or changes in anal continence were reported. The perianal disease activity index decreased from 6.4 to 1.6 (p?

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