Ontogeny of human IgE-expressing B cells and plasma cells

Ramadani F.; Bowen H.; Upton N.Hobson P. S.Chan Y. -C.Chen J. -B.Chang T. W.McDonnell J. M.Sutton B. J.Fear D. J.Gould H. J.

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Ontogeny of human IgE-expressing B cells and plasma cells

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BackgroundIgE-expressing (IgE(+)) plasma cells (PCs) provide a continuous source of allergen-specific IgE that is central to allergic responses. The extreme sparsity of IgE(+) cells in vivo has confined their study almost entirely to mouse models.

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来源
《Allergy》 |2017年第1期|66-76|共11页
作者
Ramadani F.; Bowen H.; Upton N.Hobson P. S.Chan Y. -C.Chen J. -B.Chang T. W.McDonnell J. M.Sutton B. J.Fear D. J.Gould H. J.;
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作者单位

Kings Coll London, Randall Div Cell & Mol Biohphys, London, England;

Kings Coll London, Div Asthma Allergy & Lung Biol, London, England;

Acad Sinica, Genom Res Ctr, Taipei, Taiwan;

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原文格式 PDF
正文语种英语
中图分类医学免疫学;
关键词
allergy; germinal centre; human B cells; IgE class switching; plasma cell;

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Ontogeny of human IgE-expressing B cells and plasma cells

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