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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Elevated Values of Clinically Relevant Transferases Induced by Imported Infectious Diseases: A Controlled Cross-Sectional Study of 14,559 Diseased German Travelers Returning from the Tropics and Subtropics
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Elevated Values of Clinically Relevant Transferases Induced by Imported Infectious Diseases: A Controlled Cross-Sectional Study of 14,559 Diseased German Travelers Returning from the Tropics and Subtropics

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摘要

The aim of this controlled cross-sectional study was to assess the clinical validity of elevated values of three clinically relevant transferase enzymes (aspartate transaminase AST, alanine transaminase ALT, and gamma-glutamyl transferase GGT) induced by imported infectious diseases (IDs) seen among patients consulting the Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (from 1999 to 2014) after being in the sub-/tropics. Data sets of 14,559 diseased German travelers returning from Latin America (2,715), Africa (4,574), or Asia (7,270) and of 1,536 healthy controls of German origin without recent travels were analyzed. Among the cases, the proportions of those with elevated values of AST (7.8) and of ALT (13.4) were significantly larger than among controls (4.0 and 10.6, respectively), whereas for GGT, no significant difference was found (cases: 10.0; controls: 11.4). The study identified IDs with significantly larger proportions of both AST and ALT (hepatitis A 100/100, cytomegalovirus CMV infection 77/81, chronic hepatitis C 67/67, infectious mononucleosis 65177, typhoid fever 50/50, cyclosporiasis 45/66, dengue fever 43/35, malaria 20/27, and rickettsiosis 20/24), of AST alone (paratyphoid fever 42), of ALT alone (giardiasis 20), and of GGT (hepatitis A 100, infectious mononucleosis 71, CMV infection 58, rickettsiosis (20, and dengue fever 19). The study demonstrates that the determination of AST and ALT among travelers returning from the sub-/tropics has a high clinical validity, as their elevated values are typically caused by several imported viral, bacterial, and protozoan IDs, whereas no additional clinical validity was found by the determination of GGT.

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