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首页> 外文期刊>Cell biology international. >Role of INTERLEUKIN-6 in the pathogenesis of multiple myeloma.
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Role of INTERLEUKIN-6 in the pathogenesis of multiple myeloma.

机译：INTERLEUKIN-6在多发性骨髓瘤发病机理中的作用。

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摘要

Multiple myeloma (MM) is a currently incurable disease caused by the proliferation of malignant plasma cells. Although the pathogenesis of the disease still remains unclear, recent research in the biology of MM has produced new insights into the factors that control the growth and survival of myeloma cells. Among the growth factors, interleukin-6 (IL-6) has an essential role. Evidence suggests that IL-6 is not only a growth factor, but also a survival factor in MM, inhibiting apoptosis in myeloma cells. IL-6 interacts with several factors which are involved in the pathogenesis of MM, such as adhesion molecules, tumour suppressor genes and oncogenes. Considering the essential role of IL-6, it could serve as a target for new therapeutic interventions. Neutralizing the effect of IL-6 may result in a regression of tumour progression. Copyright 2000 Academic Press.
机译：多发性骨髓瘤（MM）是目前由恶性浆细胞增殖引起的无法治愈的疾病。尽管该病的发病机理仍不清楚，但是MM生物学的最新研究对控制骨髓瘤细胞生长和存活的因素产生了新见解。在生长因子中，白介素6（IL-6）具有重要作用。有证据表明IL-6不仅是MM的一种生长因子，而且还是一种生存因子，可以抑制骨髓瘤细胞的凋亡。 IL-6与MM的发病机理中涉及的几种因素相互作用，例如粘附分子，抑癌基因和癌基因。考虑到IL-6的重要作用，它可以作为新治疗手段的靶标。中和IL-6的作用可能导致肿瘤进展的消退。版权所有2000学术出版社。

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