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Comparison of opioid receptor distributions in the rat central nervous system

机译：大鼠中枢神经系统中阿片受体分布的比较

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The opioid receptors, mu, delta and K, conduct the major pharmacological effects of opioid drugs, and exhibit intriguing functional relationships and interactions in the CNS. Previously established hypotheses regarding the mechanisms underlying these phenomena specify theoretical patterns of relative cellular locallisation for the different receptor types. In this study, we have used double-label immunohistochemistry to compare the cellular distributions of delta and K receptors with those of mu receptors in the rat CNS. Regions of established significance in opioid addiction were examined. Extensive mu/delta co-localisation was observed in neuron-like cells in several regions. mu and K receptors were also often co-localised in neuron-like cell bodies in several regions. However, intense K immunoreactivity (ir) also appeared in a separate, morphologically distinct population of cells that did not express mu receptors. These small, ovoid cells were often closely apposed against the larger, mu-ir cell bodies. Such cellular appositions were seen in several regions, but were particularly common in the medial thalamus, the periaqueductal grey and brainstem. regions. These findings support proposals that functional similarities, synergy and cooperativity between mu and delta receptors arise from widespread co-expression by cells and intracellular molecular interactions. Although co-expression of mu and K receptors was also detected, the appearance of a separate population of K-expressing cells supports proposals that the contrasting and functionally antagonistic properties of mu and K receptors are due to expression in physiologically distinct cell types. Greater understanding of opioid receptor interaction mechanisms may provide possibilities for therapeutic intervention in opioid addiction and other conditions. (c) 2006 Elsevier Inc. All rights reserved.
机译：阿片受体mu，delta和K发挥阿片类药物的主要药理作用，并在CNS中表现出有趣的功能关系和相互作用。关于这些现象的潜在机制的先前建立的假设指定了不同受体类型的相对细胞定位的理论模式。在这项研究中，我们已经使用双标记免疫组织化学来比较大鼠中枢神经系统中del和K受体与mu受体的细胞分布。检查了在阿片类药物成瘾中已建立的重要区域。在几个区域的神经元样细胞中观察到广泛的μ/δ共定位。 mu和K受体也经常共定位在几个区域的神经元样细胞体中。但是，强烈的K免疫反应性（ir）也出现在不表达mu受体的单独的，形态学上不同的细胞群中。这些小的卵形细胞通常紧贴着较大的mu-ir细胞体。这种细胞排列在几个区域可见，但在丘脑内侧，导水管周围的灰色和脑干中尤为常见。地区。这些发现支持了mu和delta受体之间的功能相似性，协同作用和协同作用的提议，这是由于细胞广泛的共表达和细胞内分子相互作用引起的。尽管还检测到mu和K受体的共表达，但是出现了单独的K表达细胞群体支持了这样的提议，即mu和K受体的对比和功能拮抗特性是由于在生理上不同的细胞类型中表达所致。对阿片类药物受体相互作用机制的更多了解可能为阿片类药物成瘾和其他疾病的治疗干预提供可能性。 （c）2006 Elsevier Inc.保留所有权利。

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