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首页> 外文期刊>Life sciences >Acetaldehyde induces histamine release from purified rat peritoneal mast cells
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Acetaldehyde induces histamine release from purified rat peritoneal mast cells

机译：乙醛诱导组胺从纯化的大鼠腹膜肥大细胞中释放

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Acetaldehyde is a widely distributed compound in the human environment and it is also formed in the human body from various endogenous and exogenous sources, exogenous ethanol being the most important one. Many alcohol-associated hypersensitivity reactions, e.g. Oriental flushing reaction, appear to be attributable to acetaldehyde rather than to ethanol itself. The pathogenetic mechanism behind such hypersensitivity reactions has been suggested to be histamine release from mast cells or blood basophils. However, the direct effects of acetaldehyde on mast cells, the main source of histamine in a mammalian body, have not been studied. The aim of the present study was, thus, to evaluate whether physiological concentrations of acetaldehyde could release histamine from purified rat peritoneal mast cells. The effects of ethanol were studied similarly. The results show that acetaldehyde, already at a concentration of 50 mu M, significantly increases the release of histamine from mast cells. Ethanol has a similar effect but only at molar concentrations. These results indicate that acetaldehyde may contribute to the development of various hypersensitivity reactions by directly increasing histamine release from mast cells. [References: 54]
机译：乙醛是在人类环境中广泛分布的化合物，并且它也是在人体中由各种内源性和外源性来源形成的，外源性乙醇是最重要的一种。许多酒精相关的超敏反应，例如东方的冲洗反应似乎归因于乙醛而不是乙醇本身。已经表明这种超敏反应背后的致病机制是肥大细胞或血液嗜碱性粒细胞释放组胺。但是，尚未研究乙醛对肥大细胞（哺乳动物体内组胺的主要来源）的直接作用。因此，本研究的目的是评估生理浓度的乙醛是否可以从纯化的大鼠腹膜肥大细胞中释放组胺。类似地研究了乙醇的作用。结果表明，乙醛浓度已经达到50μM，显着增加了肥大细胞中组胺的释放。乙醇具有类似的作用，但仅在摩尔浓度下有效。这些结果表明乙醛可通过直接增加肥大细胞中的组胺释放来促进各种超敏反应的发展。 [参考：54]

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