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Cross tolerance to environmental stress and endotoxin

机译：对环境压力和内毒素的交叉耐受

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Mild DIC-like phenomena develop in rodents exposed to environmental stress, induced by prolonged fluctuation in ambient temperature, known as SART (specific alternation of rhythm in temperature) stress, the symptoms being essentially similar to those produced by endotoxin. The aim of the present study was to investigate whether common mechanisms are involved in the stress-induced DIC-like phenomena and endotoxaemia. The mortality in mice after intraperitoneal injection with endotoxin at 8.3, 16.7 and 33.3 mg/kg increased in a dose-dependent manner. In the mice exposed to stress for 7 days, the death rate following endotoxin at 8.3 mg/kg was markedly lower than that in unstressed mice, although no difference was detected between the two groups following endotoxin at 16.7 and 33.3 mg/kg. Conversely, repeated administration of endotoxin at a low dose, 0.5 mg/kg, during exposure to stress for 7 days inhibited the stress-induced thrombocytopenia and hypofibrinogenemia. These findings indicate the development of cross tolerance to prolonged environmental stress and endotoxin, implying involvement of a common mechanism. (C) 1998 Elsevier Science Inc. [References: 21]
机译：在长时间暴露于环境温度下的啮齿动物中，会出现轻度的DIC现象，这是由于环境温度的长时间波动而引起的，称为SART（温度的特定变化）应激，其症状与内毒素产生的症状基本相似。本研究的目的是调查在压力诱导的DIC样现象和内毒素血症中是否涉及共同的机制。腹膜内注射8.3、16.7和33.3 mg / kg内毒素后小鼠的死亡率呈剂量依赖性。暴露于应激7天的小鼠中，内毒素8.3 mg / kg的死亡率显着低于未受应激的小鼠，尽管两组内毒素16.7和33.3 mg / kg的死亡率无差异。相反，在暴露于压力下7天期间以低剂量0.5 mg / kg的低剂量重复施用内毒素可抑制压力诱导的血小板减少和血纤维蛋白原减少。这些发现表明对延长的环境压力和内毒素的交叉耐受性的发展，这暗示了共同机制的参与。 （C）1998 Elsevier Science Inc. [参考：21]

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