Impact of Multiplicity of Plasmodium falciparum Infection on Clinical Disease in Malawi

Dominique Earl; Andrea G. Buchwald; Alick SixpenceMabvuto ChimenyaMilius DamsonKarl B. Seydel

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Impact of Multiplicity of Plasmodium falciparum Infection on Clinical Disease in Malawi

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Abstract. Multiplicity of infection (MOI), the number of unique Plasmodium falciparum parasite genotypes found in one infected individual, may contribute to the development of clinical malaria disease. However, the independent contribution of MOI and parasite density to clinical disease has not been well characterized. We conducted a two-year longitudinal cohort study of adults and children in a high-transmission setting in Malawi to test the hypothesis that increased MOI was independently associated with clinical disease, after accounting for parasite density. Of 1,062 episodes of infection

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《The American Journal of Tropical Medicine and Hygiene》 |2019年第2期|412-415|共4页
作者
Dominique Earl; Andrea G. Buchwald; Alick SixpenceMabvuto ChimenyaMilius DamsonKarl B. Seydel;
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Center for Vaccine Development and Global Health, University of Maryland School of Medicine;

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正文语种英语
中图分类地方病学;
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Impact of Multiplicity of Plasmodium falciparum Infection on Clinical Disease in Malawi

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