Salvinorin A: A novel and highly selective kappa-opioid receptor agonist

Feng Y; Roth BL

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Salvinorin A: A novel and highly selective kappa-opioid receptor agonist

机译：Salvinorin A：一种新型且高度选择性的κ阿片受体激动剂

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K-opioid receptors (KORs) represent the principal site of action of dynorphin and related neuropeptides. Recently, Salvinorin A-a naturally occurring neoclerodane diterpene hallucinogen was identified to be a highly selective KOR agonist. In this brief review we summarize the known chemistry, pharmacology and biology of salvinorin A. Because salvinorin A profoundly alters human consciousness and perception, a study of how salvinorin A exerts its actions on KORs may yield novel insights into the molecular and cellular basis of uniquely human higher cortical functions. (C) 2004 Elsevier Inc. All rights reserved.

机译：K阿片受体（KOR）代表强啡肽和相关神经肽的主要作用部位。最近，Salvinorin A-一种天然存在的新环戊二烯双萜致幻剂被鉴定为高度选择性的KOR激动剂。在这篇简短的综述中，我们总结了萨尔维诺林A的已知化学，药理学和生物学。由于萨尔维诺林A深刻改变了人类的意识和知觉，因此对萨尔维诺林A如何对KOR发挥作用的研究可能会产生独特的分子和细胞基础的新见解。人类更高的皮层功能。（C）2004 Elsevier Inc.保留所有权利。

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《Life sciences》 |2004年第22期|共5页
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Feng Y; Roth BL;
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正文语种 eng
中图分类生命的起源;
关键词
kappa-opioid receptors; kappa-opioid agonists; salvinorin A; SALVIA-DIVINORUM; HALLUCINOGEN; SYSTEM;

机译：κ阿片受体;κ阿片受体激动剂;Salvinorin A;SALVIA-DIVINORUM;致幻剂;系统;

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1. N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy. [J] . Beguin C, Potter DN, Dinieri JA, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2008,第1期

机译：Salvinorin A的N-甲基乙酰胺类似物：一种高效且选择性的κ阿片受体激动剂，具有口服功效。
2. Salvinorin A,an Active Component of the Hallucinogenic Sage Sa/via divinorum Is a Highly Efficacious kappa-Opioid Receptor Agonist:Structural and Functional Considerations [J] . Charles Chavkin, Sumit Sud The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2004,第3期

机译：Salvinorin A，致幻鼠尾草Sa / via divinorum的活性成分，是高效的阿片受体激动剂：结构和功能上的考虑
3. Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective kappa-opioid receptor agonists [J] . Lee David Y. W., Deng Gang, Ma Zhongze, Bioorganic and Medicinal Chemistry Letters . 2015,第20期

机译：选择性κ-阿片受体激动剂2-烷基-2-甲氧基甲基-salvinorin醚的合成及生物学评价
4. The development of a novel highly selective and potent agonist for human melanocortin 4 receptor [C] . Malcolm Kavarana, M.Cai, D.Trivedi, the International Peptide Symposium . 2001

机译：一种新颖的人黑素激素4受体的高精度和有效激动剂的发展
5. Molecular mechanisms by which salvinorin A binds to and activates the kappa-opioid receptor. [D] . Yan, Feng. 2008

机译：Salvinorin A结合并激活κ阿片受体的分子机制。
6. Neuroprotective actions of GR89696 a highly potent and selective kappa-opioid receptor agonist. [O] . P. J. Birch, H. Rogers, A. G. Hayes, 1991

机译：GR89696是一种高度有效的选择性κ阿片受体激动剂具有神经保护作用。
7. Salvinorin A, a kappa-opioid receptor (KOP-r) agonist hallucinogen: Pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders [O] . Eduardo eButelman, Mary Jeanne eKreek 2015

机译：salvinorin a，一种κ-阿片受体（KOp-r）激动剂迷幻剂：神经精神疾病中新型药物治疗药物的药理学和潜在模板

Salvinorin A: A novel and highly selective kappa-opioid receptor agonist

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