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Effects of spontaneous and forced running on activation of hypothalamic corticotropin-releasing hormone neurons in rats

机译：自发和强迫跑步对大鼠下丘脑促肾上腺皮质激素释放激素神经元活化的影响

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Corticotropin-releasing hormone (CRH)-containing neurons in the hypothalamic paraventricular nucleus (PVN) are known to be activated during physical or psychological stress, and play an important role as one of the central activators of integrated stress response. Physical exercise has also been suggested as one of the stressors activating CRH neurons in the PVN. Spontaneous wheel running (SWR) has recently been reported to result in improved mental health or mood, unlike treadmill running that commonly forces the animal to run. Thus, forced running may strongly induce an activation of CRH neurons compared with spontaneous running, and spontaneous running may not represent a strong stressor. However, whether the effects of spontaneous running on activation of CRH neurons in the PVN differ from those of forced running is unknown. The present study examined the activity of CRH neurons in 1-h forced wheel running (FWR) and SWR using c-Fos/CRH immunohistochemistry in male Wistar rats. No significant differences hi 1-h running distance were observed between FWR and SWR, indicating that amount of work was almost equal between exercises. Number of double-labeled neurons for c-Fos and CRH in the PVN was markedly higher hi FWR than hi SWR. In addition, no significant differences in Fos expression in the LC, which is related to various stress responses, were found between FWR and SWR. These results indicate that FWR strongly activates CRH neurons in the PVN compared with SWR, suggesting that spontaneous running is not an intense stressor even though running distance does not differ significantly from forced running. 500Exercise; Stress; Paraventricular nucleus; Immunohistochemistry
机译：下丘脑室旁核（PVN）中含有促肾上腺皮质激素释放激素（CRH）的神经元已知在生理或心理压力下被激活，并作为综合应激反应的中央激活剂之一发挥重要作用。还建议进行体育锻炼，作为激活PVN中CRH神经元的应激源之一。最近有报道称，自发性滚轮跑步（SWR）可以改善精神健康或情绪，这与通常迫使动物奔跑的跑步机不同。因此，与自然跑步相比，强迫跑步可能强烈诱导CRH神经元的激活，并且自然跑步可能并不代表强烈的压力源。然而，尚不清楚自发奔跑对PVN中CRH神经元激活的影响是否与强制奔跑的影响不同。本研究使用c-Fos / CRH免疫组化技术在雄性Wistar大鼠中检查了1小时强迫行车（FWR）和SWR中CRH神经元的活性。 FWR和SWR在1小时跑步距离上没有观察到显着差异，表明锻炼之间的工作量几乎相等。 PVN中c-Fos和CRH的双标记神经元数量显着高于hi SWR。此外，在FWR和SWR之间，未发现LC中Fos表达的显着差异，该差异与各种应力响应有关。这些结果表明，与SWR相比，FWR强烈激活了PVN中的CRH神经元，这表明自发奔跑并不是强烈的压力源，即使奔跑距离与强制奔跑没有明显不同。 500运动;强调;脑室旁核;免疫组织化学

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