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Improvement in cholesterol metabolism in mice given chronic treatment of taurine and fed a high-fat diet

机译：长期服用牛磺酸和高脂饮食的小鼠胆固醇代谢的改善

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The effects of chronic treatment of taurine can hypercholesterolemia and atherosclerosis were examined in C57BL/6J mice fed a high-fat diet containing 15% fat and 1.25% cholesterol. Taurine was dissolved in drinking water at 1% (whv) and was given to mice ad libitum during 6 months-feeding of a high-fat diet. Hypercholesterolemia occurred and lipid accumulation on the aortic valve was evident. Taurine treatment lowered serum LDL + VLDL cholesterol by 44% in mice fed a high-fat diet, while it elevated serum HDL cholesterol by 25%. As a result, the atherogenic index, the ratio of HDL to LDL + VLDL was markedly improved. Cholesterol content in the liver also decreased by 19% with taurine. Similar tendencies were seen in mice fed regular chow, but the changes were not significant. The area of aortic lipid accumulation, which served as an index of atherosclerosis, was reduced by 20% with taurine. In the liver, taurine doubled the activity of cholesterol 7 alpha-hydoxylase. These observations, together with prior findings, suggest that the cholesterol-lowering action of taurine may relate to the increased conversion of cholesterol to bile acids via stimulation of cholesterol 7 alpha-hydroxylase activity. Thus, chronic treatment of high-fat mice with taurine improves the abnormal profile of the serum lipoproteins, and thereby retards the progression of atherosclerosis. [References: 40]
机译：在饲喂高脂饮食（含15％脂肪和1.25％胆固醇）的C57BL / 6J小鼠中，检查了牛磺酸可长期治疗胆固醇过多和动脉粥样硬化的效果。牛磺酸以1％（whv）的浓度溶解在饮用水中，并在喂食高脂饮食的6个月期间随意喂给小鼠。发生高胆固醇血症，主动脉瓣上脂质堆积明显。牛磺酸治疗可使高脂饮食小鼠的血清LDL + VLDL胆固醇降低44％，而使血清HDL胆固醇升高25％。结果，显着改善了动脉粥样硬化指数，HDL与LDL + VLDL的比例。牛磺酸可使肝脏中的胆固醇含量降低19％。在喂普通食物的小鼠中也观察到了类似的趋势，但是变化并不明显。牛磺酸可将作为动脉粥样硬化指标的主动脉脂质积聚面积减少20％。在肝脏中，牛磺酸使胆固醇7α-羟化酶的活性增加了一倍。这些观察结果以及先前的发现表明，牛磺酸的降低胆固醇的作用可能与通过刺激胆固醇7α-羟化酶的活性而使胆固醇向胆汁酸的转化增加有关。因此，用牛磺酸对高脂小鼠进行长期治疗可改善血清脂蛋白的异常状况，从而延缓动脉粥样硬化的发展。 [参考：40]

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