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首页> 外文期刊>Cellular immunology >Discrimination between receptor- and store-operated Ca2+ influx in human neutrophils
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Discrimination between receptor- and store-operated Ca2+ influx in human neutrophils

机译：区分人类嗜中性粒细胞的受体操纵性和储存操纵性Ca2 +流入

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Ca2+ and Sr2+ entry pathways activated by pro-inflammatory agonists FMLP, LTB4 and PAF have been compared to thapsigargin in human neutrophils. 2-APB (10μM) increased Ca2+ influx and to a greater extent in agonist than in thapsigargin stimulated neutrophils. This action of 2-APB was specific to Ca2+ because 2-APB did not augment Sr2+ entry in agonist and thapsigargin stimulated neutrophils. This suggests that Ca2+ and Sr2+ entry can be used to discriminate between receptor and non-receptor (store)-operated Ca2+ influx. Our data show for the first time that Pyr3 whilst partially inhibiting agonist induced Ca2+ influx almost completely abolished Ca2+ influx after thapsigargin stimulation.
机译：在人类嗜中性粒细胞中，由促炎性激动剂FMLP，LTB4和PAF激活的Ca2 +和Sr2 +进入途径已与毒胡萝卜素进行了比较。与毒胡萝卜素刺激的中性粒细胞相比，2-APB（10μM）增加了Ca2 +内流，并且在激动剂中的作用更大。 2-APB的这种作用特定于Ca2 +，因为2-APB不会增加激动剂和毒胡萝卜素刺激的嗜中性粒细胞中Sr2 +的进入。这表明Ca2 +和Sr2 +进入可用于区分受体和非受体（存储）操纵的Ca2 +内流。我们的数据首次表明，Pyr3在部分抑制激动剂诱导的Ca2 +内流的同时几乎完全消除了毒胡萝卜素刺激后的Ca2 +内流。

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