• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Redox report: communications in free radical research >Glutathione reductase is expressed at high levels in pancreatic islet cells
【24h】

Glutathione reductase is expressed at high levels in pancreatic islet cells

机译：谷胱甘肽还原酶在胰岛细胞中高水平表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Reactive oxygen species are, at least partly, involved in the diabetogenic agent-induced dysfunction of pancreatic β-cells because the expression of antioxidative and redox proteins is low. We examined the levels of antioxidant/redox proteins, peroxiredoxins-1, -4, and -6 and glutathione reductase (GR), by immunohistochemistry and found that the expression of GR was very high in pancreatic islet cells compared to exocrine cells. When diabetes was induced by an intravenous injection of streptozotocin, the pre-administration of 1,3-bis[2-chloroethyl]-1-nitrosourea, an irreversible inhibitor of GR, made islet cells more vulnerable to streptozotocin. These data point to a pivotal role of the glutathione redox system in pancreatic islet cells against diabetogenic stress.
机译：由于抗氧化蛋白和氧化还原蛋白的表达很低，因此活性氧至少部分地参与了糖尿病患者诱导的胰岛β细胞功能障碍。我们通过免疫组织化学检查了抗氧化剂/氧化还原蛋白，过氧化物歧蛋白-1，-4和-6和谷胱甘肽还原酶（GR）的水平，发现胰腺胰岛细胞中的GR表达与外分泌细胞相比非常高。当静脉注射链脲佐菌素诱发糖尿病时，不可逆的GR抑制剂1,3-双[2-氯乙基] -1-亚硝基脲的预先给药会使胰岛细胞更容易受到链脲佐菌素的伤害。这些数据表明谷胱甘肽氧化还原系统在胰岛细胞中对抗糖尿病形成应激的关键作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号