首页> 外文期刊>Cellular immunology >Protective role of the vitamin D receptor
【24h】

Protective role of the vitamin D receptor

机译:维生素D受体的保护作用

获取原文
获取原文并翻译 | 示例
           

摘要

Vitamin D receptor (VDR) is found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney. The nonclassic actions are therefore potential targets for the active metabolite of vitamin D, 1,25(OH)2D3. This review is intended to highlight the actions of VDR in role of protection. Medline is searched for articles describing actions of VDR on secondary hyperparathyroidism, diabetic nephropathy, hypertension and atherosclerosis. VDR exerts its protective activities through the following mechanisms: inhibition of renin-angiotensin system (RAS); regulation of proliferation and differentiation; reduction of proteinuria; anti-inflammation and anti-fibrosis. The nonclassic actions of VDR provide a number of potential new clinical applications for 1,25(OH)2D3 and its analogs. We believe 1,25(OH)2D3/VDR can be of particular value in the prevention of kidney-related diseases.
机译:维生素D受体(VDR)存在于大多数组织中,而不仅仅是那些参与维生素D经典动作的组织,例如骨骼,肠胃和肾脏。因此,非经典作用是维生素D 1,25(OH)2D3活性代谢物的潜在目标。此次审核旨在强调VDR在保护角色中的作用。在Medline中搜索描述VDR对继发性甲状旁腺功能亢进,糖尿病性肾病,高血压和动脉粥样硬化作用的文章。 VDR通过以下机制发挥保护作用:抑制肾素-血管紧张素系统(RAS);调节增殖和分化;减少蛋白尿;抗发炎和抗纤维化。 VDR的非经典作用为1,25(OH)2D3及其类似物提供了许多潜在的新临床应用。我们认为1,25(OH)2D3 / VDR在预防肾脏相关疾病方面可能具有特殊价值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号