• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular immunology >Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis.
【24h】

Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis.

机译：血管活性肠肽对胶原诱导的关节炎中Treg和Th17平衡的调节作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Vasoactive intestinal peptide (VIP) is a well-known anti-inflammatory neuropeptide. The capacity of VIP can be exhibited through inhibiting inflammatory responses, shifting the Th1/Th2 balance in favor of anti-inflammatory Th2 immunity and inducing regulatory T cells (Tregs) with suppressive activity. In addition to pro-inflammatory Th1 response, Th17 are also believed to play important roles in the pathogenesis of rheumatoid arthritis (RA). In this study, we used collagen-induced arthritis (CIA) model in Wistar rats to investigate the role of VIP in the balance of CD4(+) CD25(+) Tregs and Th17 on RA. Data presented here showed that administration of VIP decreased incidence and severity of CIA. Disease suppression was associated with the upregulation of CD4(+) CD25(+) Tregs, downregulation of Th17- and Th1-type response and influence on the RANK/RANKL/OPG system. The results provide novel evidence that the therapeutic effects of VIP on CIA rats were associated with the balance of CD4(+) CD25(+) Tregs and Th17.
机译：血管活性肠肽（VIP）是众所周知的抗炎性神经肽。 VIP的能力可以通过抑制炎症反应，改变Th1 / Th2平衡以增强抗炎Th2免疫力以及诱导具有抑制活性的调节性T细胞（Tregs）来展现。除促炎性Th1反应外，Th17还被认为在类风湿关节炎（RA）的发病机理中起重要作用。在这项研究中，我们使用Wistar大鼠胶原诱导的关节炎（CIA）模型来研究VIP在RA中CD4（+）CD25（+）Treg和Th17平衡中的作用。此处提供的数据表明VIP的使用降低了CIA的发生率和严重程度。疾病抑制与CD4（+）CD25（+）Tregs的上调，Th17-型和Th1型应答的下调以及对RANK / RANKL / OPG系统的影响有关。结果提供了新的证据，表明VIP对CIA大鼠的治疗作用与CD4（+）CD25（+）Tregs和Th17的平衡有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号