Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.

Popowicz GM; Czarna A; Holak TA

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Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.

机译：人Mdmx蛋白的结构与p53肿瘤抑制因子反式激活域结合。

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The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ineffective in the Mdmx-p53 interaction.

机译：Mdmx癌蛋白只是最近才出现，与p53激活的Mdm2调节因子无关。我们已经确定了与人p53的15个残基的反式激活域肽结合的人Mdmx N末端域的晶体结构。该结构显示了Mdm2与p53结合的拮抗剂为何在Mdmx-p53相互作用中无效。

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《Cell cycle》 |2008年第15期|共3页
作者
Popowicz GM; Czarna A; Holak TA;
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正文语种 eng
中图分类细胞生物学;
关键词
Human; structure; Proteins; Neoplasms; 蛋白质类; 肿瘤;

机译：Human;structure;Proteins;Neoplasms;蛋白质类;肿瘤;

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专利

1. Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. [J] . Popowicz GM, Czarna A, Holak TA Cell cycle . 2008,第15期

机译：人Mdmx蛋白的结构与p53肿瘤抑制因子反式激活域结合。
2. STRUCTURE OF THE MDM2 ONCOPROTEIN BOUND TO THE P53 TUMOR SUPPRESSOR TRANSACTIVATION DOMAIN [J] . Kussie PH, Gorina S, Marechal V, Science . 1996,第5289期

机译：绑定到P53肿瘤抑制子交易域的MDM2癌蛋白的结构
3. Transactivation of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors. [J] . B Roy, J Beamon, E Balint, Molecular and Cellular Biology . 1994,第12期

机译：c-Myc / Max对人类p53抑癌基因的反式激活导致某些肿瘤中突变p53的表达升高。
4. Clustering Protein-Protein Interaction Network of TP53 Tumor Suppressor Protein using Markov Clustering Algorithm [C] . Thia Sabel Permata, Alhadi Bustamam International Conference on Advanced Computer Science and Information Systems . 2015

机译：使用Markov聚类算法的TP53肿瘤抑制蛋白的聚类蛋白 - 蛋白质相互作用网络
5. The tumor suppressor protein p53 and the antagonizing oncoprotein E6 from human papillomavirus type 16 [D] . Malecka, Kimberly Ann 2010

机译：人类乳头瘤病毒16型的抑癌蛋白p53和拮抗癌蛋白E6
6. Transactivation of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors. [O] . B Roy, J Beamon, E Balint, 1994

机译：c-Myc / Max对人类p53抑癌基因的反式激活导致某些肿瘤中突变p53的表达升高。
7. Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. [O] . Wells, Mark, Tidow, Henning, Rutherford, Trevor J, 2008

机译：肿瘤抑制因子p53的结构及其固有的N末端反式激活结构域。
8. SV40 large tumor antigen and the tumor suppressor p53 are phosphorylated by a DNA-activated protein kinase from human cells. [R] . Lees-Miller, S. P., Chen, Y. R., Anderson, C. W. 1990

机译：sV40大肿瘤抗原和肿瘤抑制因子p53被来自人细胞的DNa活化蛋白激酶磷酸化。

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.

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