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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >The lymph node ratio as prognostic factor in node-positive breast cancer.
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The lymph node ratio as prognostic factor in node-positive breast cancer.

机译：淋巴结比率是淋巴结阳性乳腺癌的预后因素。

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BACKGROUND AND PURPOSE: The clinical records of the node-positive breast cancer patients treated at our department were reviewed, to evaluate if there is a correlation between the ratio of involved axillary lymph nodes and the overall and cause specific survival. PATIENTS AND METHODS: From 1984 until July 2001, 2073 files from patients with an invasive breast carcinoma were submitted to retrospective analyses. In 810 cases, a node positive status was diagnosed. All pT-stages were included. The total number of dissected nodes (pNtot) and the number of involved nodes (pN+) were available for 741 patients. The ratio of nodal involvement (pN+%) was categorized into three groups, pN+%< or =10% (n = 212) between 11 and 50% (n = 346) and between 51 and 100% (n = 183). RESULTS: The actuarial overall survival (OS) at 5 and 10 years was, respectively, 78.2 and 59.1%. Cause specific survival (CSS) rates were, respectively, 83.6 and 69.1%. In univariate analyses, age (P = 0.01), grade (P = 0.02), pT-stage (P < 0.0001), chemotherapy (P = 0.0002), the number of involved nodes < or =3 versus >3 (pN+) (P < 0.0001) and ratio pN+% (P < 0.0001) were associated significantly with overall survival. A multivariate analysis using the Cox proportional hazards model found that pN+% was the most significant prognostic factor; pN+lost significance when pN+% was taken into account. CONCLUSIONS: The percentage of positive lymph nodes in an axillary lymph node dissection appears to be an important prognostic factor for survival. The nodes ratio improved on the absolute numbers of involved axillary lymph nodes for assessment of prognosis.
机译：背景与目的：回顾了我科治疗的淋巴结阳性乳腺癌患者的临床记录，以评估受累腋窝淋巴结的比例与总体和特定生存率之间是否存在相关性。患者与方法：从1984年至2001年7月，对2073例浸润性乳腺癌患者的文件进行了回顾性分析。在810例病例中，诊断出淋巴结阳性。包括所有的pT阶段。 741名患者可获得解剖结节总数（pNtot）和受累结节数目（pN +）。淋巴结受累的比率（pN +％）分为三组，pN +％<或= 10％（n = 212）在11％和50％之间（n = 346），在51％和100％之间（n = 183）。结果：5年和10年的精算总生存率分别为78.2％和59.1％。原因特定生存率（CSS）分别为83.6和69.1％。在单变量分析中，年龄（P = 0.01），等级（P = 0.02），pT分期（P <0.0001），化疗（P = 0.0002），受累结节数<或= 3与> 3（pN +）（ P <0.0001）和比率pN +％（P <0.0001）与总体生存率显着相关。使用Cox比例风险模型进行的多变量分析发现，pN +％是最重要的预后因素。当考虑到pN +％时，pN +失去显着性。结论：腋窝淋巴结清扫阳性淋巴结的百分比似乎是生存的重要预后因素。淋巴结比率的提高有助于评估受累腋窝淋巴结的绝对数量。

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