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首页> 外文期刊>Biochemistry >Y-Box-Binding Protein 1 (YB-1) and Its Functions
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Y-Box-Binding Protein 1 (YB-1) and Its Functions

机译：Y盒结合蛋白1（YB-1）及其功能

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摘要

This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the participation of YB-1 in DNA reparation and transcription, mRNA splicing and translation are systematized. Results on interactions of YB-1 with cytoskeleton components and its possible role in mRNA localization are discussed. Data on intracellular distribution of YB-1, its redistribution between the nucleus and the cytoplasm, and its secretion and extracellular functions are summarized. The effect of YB-1 on cell differentiation, its involvement in extra- and intracellular signaling pathways, and its role in early embryo-genesis are described. The mechanisms of regulation of YB-1 expression in the cell are presented. Special attention is paid to the involvement of YB-1 in oncogenic cell transformation, multiple drug resistance, and dissemination of tumors. Both the oncogenic and antioncogenic activities of YB-1 are reviewed. The potential use of YB-1 in diagnostics and therapy as an early cancer marker and a molecular target is discussed.
机译：这篇综述描述了Y盒结合蛋白1（YB-1）的结构和功能及其同源物。考虑了YB-1与DNA，mRNA和蛋白质的相互作用。有关YB-1参与DNA修复和转录，mRNA剪接和翻译的数据已系统化。讨论了YB-1与细胞骨架成分相互作用的结果及其在mRNA定位中的可能作用。总结了有关YB-1的细胞内分布，其在细胞核与细胞质之间的重新分布以及其分泌和细胞外功能的数据。描述了YB-1对细胞分化的影响，其参与细胞外和细胞内信号通路的作用及其在早期胚胎发生中的作用。提出了调节细胞中YB-1表达的机制。特别注意YB-1参与致癌细胞转化，多重耐药性和肿瘤扩散。审查了YB-1的致癌和抗癌活性。讨论了YB-1作为早期癌症标志物和分子靶标在诊断和治疗中的潜在用途。

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