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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Can we reduce the incidence of second primary malignancies occurring after radiotherapy?
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Can we reduce the incidence of second primary malignancies occurring after radiotherapy?

机译：我们是否可以减少放疗后发生的第二原发性恶性肿瘤的发生率？

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摘要

The discussion of the potential risk of second cancer induction by curative radiotherapy of the first cancer is a recent phenomenon. This is surprising, as during the follow-up of treated patients doctors, carefully searching for local recurrence of the treated primary or for distant metastasis, often inadvertently come across another malignancy which clearly is a new, an independent second cancer. Again and again, doctors and patients probably wondered whether the second cancer was the direct result of the treatment of the first cancer and in particular, whether radiation being a well known carcinogenic agent had caused the second cancer. In hindsight, it is difficult to understand why there has been so little research into this most serious potential complication of radiotherapy while radiobiologists and radiotherapists kept concentrating on investigating the pathogenesis and the risks of much less severe normal tissue effects and on how to avoid them
机译：最近的现象是关于通过对第一种癌症进行根治性放射疗法诱发第二种癌症的潜在风险的讨论。这是令人惊讶的，因为在对接受治疗的患者医生进行随访期间，仔细地寻找所治疗的原发灶的局部复发或远处转移，常常会无意中遇到另一种恶性肿瘤，显然这是一种新的，独立的第二种癌症。医生和患者一次又一次地想知道第二种癌症是否是第一种癌症治疗的直接结果，特别是，作为一种众所周知的致癌剂的辐射是否引起了第二种癌症。事后看来，很难理解为什么对放疗这种最严重的潜在并发症的研究如此之少，而放射生物学家和放射治疗师却一直专注于调查其发病机理以及严重程度低于正常组织的风险以及如何避免这些疾病的风险。

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