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首页> 外文期刊>Cell cycle >Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases.
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Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases.

机译：Abl酪氨酸激酶调节Rho家族GTPases上游和下游的钙黏着蛋白依赖性粘附。

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摘要

Formation and dissolution of intercellular adhesions are processes of paramount importance during tissue morphogenesis and for pathological conditions such as tumor metastasis. Cadherin-mediated intercellular adhesion requires dynamic regulation of the actin cytoskeleton. The pathways that link cadherin signaling to cytoskeletal regulation remain poorly defined. We have recently uncovered a novel role for the Abl family of tyrosine kinases linking cadherin-mediated adhesion to actin dynamics via the regulation of Rho family GTPases. Abl kinases are activated by cadherin engagement, localize to cell-cell junctions and are required for the formation of adherens junctions. Notably, we showed that Abl kinases are required for Rac activation during formation of adherens junctions, and also regulate a Rho-ROCK-myosin signaling pathway that is required for the maintenance of intercellular adhesion. Here we show that Abl kinases regulate the formation and strengthening of adherens junctions downstream of active Rac, and that Abl tyrosine kinases are components of a positive feed-back loop that employs the Crk/CrkL adaptor proteins to promote the formation and maturation of adherens junctions.
机译：细胞间粘连的形成和溶解是组织形态发生过程中以及病理条件（例如肿瘤转移）过程中至关重要的过程。钙黏着蛋白介导的细胞间粘附需要动态调节肌动蛋白的细胞骨架。将钙黏着蛋白信号传导与细胞骨架调节联系起来的途径仍然不清楚。我们最近发现了酪氨酸激酶Abl家族的一个新角色，该家族通过Rho家族GTPases的调节将钙黏着蛋白介导的粘附与肌动蛋白动力学联系起来。 Abl激酶通过钙黏着蛋白的结合被激活，定位于细胞-细胞连接处，并且是形成粘附连接所必需的。值得注意的是，我们表明Abl激酶是粘附连接形成过程中Rac激活所必需的，并且还调节维持细胞间粘附所需的Rho-ROCK-肌球蛋白信号传导途径。在这里，我们显示Abl激酶调节活性Rac下游粘附连接的形成和加强，而Abl酪氨酸激酶是正反馈回路的组成部分，该反馈回路利用Crk / CrkL衔接蛋白促进粘附连接的形成和成熟。 。

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