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Regulation of cardiomyocyte proliferation by Foxp1.

机译:Foxp1对心肌细胞增殖的调节。

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摘要

The heart is the first organ to develop and function during embryogenesis. Cardiomyocytes proliferate extensively during prenatal development but withdraw from the cell cycle soon after birth.1 This results in terminally differentiated adult cardiomyocytes incapable of proliferation, which severely limits the response of the adult heart to injury. Although the signaling pathways involved in the proliferation, differentiation and survival of developing and adult cardiomyocytes have been studied extensively, little is understood about the precise mechanisms that regulate their almost permanent exit from the cell cycle.
机译:心脏是胚胎发生过程中发育并起作用的第一器官。心肌细胞在产前发育期间大量增殖,但在出生后不久便退出细胞周期。1这导致最终分化的成年心肌细胞无法增殖,从而严重限制了成年心脏对损伤的反应。尽管已广泛研究了涉及发育中的和成年心肌细胞的增殖,分化和存活的信号传导途径,但对调节其几乎永久退出细胞周期的精确机制了解甚少。

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