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TRPs in the brain

机译：大脑中的TRP

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摘要

The Transient receptor potential (TRP) family of cation channels is a large protein family, which is mainly structurally uniform. Proteins consist typically of six transmembrane domains and mostly four subunits are necessary to form a functional channel. Apart from this, TRP channels display a wide variety of activation mechanisms (ligand binding, G-protein coupled receptor dependent, physical stimuli such as temperature, pressure, etc.) and ion selectivity profiles (from highly Ca2+ selective to non-selective for cations). They have been described now in almost every tissue of the body, including peripheral and central neurons. Especially in the sensory nervous system the role of several TRP channels is already described on a detailed level. This review summarizes data that is currently available on their role in the central nervous system. TRP channels are involved in neurogenesis and brain development, synaptic transmission and they play a key role in the development of several neurological diseases.
机译：阳离子通道的瞬时受体电位（TRP）家族是一个大蛋白家族，主要在结构上均一。蛋白质通常由六个跨膜结构域组成，大多数情况下，四个亚基是形成功能性通道所必需的。除此之外，TRP通道还具有多种激活机制（配体结合，G蛋白偶联受体依赖性，物理刺激（例如温度，压力等））和离子选择性分布（从对阳离子的高Ca2 +选择性到非选择性） ）。现在，几乎在人体的每个组织（包括外周神经和中枢神经元）中都对它们进行了描述。特别是在感觉神经系统中，已经详细描述了多个TRP通道的作用。这篇综述总结了目前有关其在中枢神经系统中作用的数据。 TRP通道参与神经发生和大脑发育，突触传递，并且在几种神经系统疾病的发生中起关键作用。

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