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Characteristics of Sj?gren's syndrome in rheumatoid arthritis

机译：类风湿关节炎的干燥综合征特征

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摘要

Objective: To compare features of SS in RA with primary SS and RA without SS. Methods: Patients hospitalized between January 2007 and December 2010 were retrospectively studied. Seventy four cases of overlap RA and SS (RA/SS) among 509 cases of RA were identified. Cases of SS (n = 187) detected during the same period acted as controls. Results: Among those with RA/SS, there were 46 cases of RA onset SS and 12 cases of SS onset RA. Sixteen patients had simultaneous onset RA and SS. Compared with RA without SS, RA/SS patients had more severe arthritis; a higher incidence of haematological abnormality, fever and rash; and a higher frequency of RF, ANAs and anti SSA and anti SSB antibodies (P<0.05). Compared with primary SS, RA/SS patients were older, had more severe arthritis, anaemia and lung involvement; a lower incidence of fever, rash, leucopenia, thrombocytopenia and hyperthyroidism; and a higher frequency of RF, anti keratin antibody, anti perinuclear factor and anti cyclic citrullinated antibodies (P<0.05). Compared with RA and primary SS, RA/SS patients had higher disease activity scores of both RA and SS. Conclusion: RA/SS patients have distinctive features, with more complications and systemic involvement. In addition, disease activity is higher in RA/SS.
机译：目的：比较伴有原发性SS和不伴有SS的RA中SS的特征。方法：回顾性分析2007年1月至2010年12月期间住院的患者。在509例RA中鉴定出74例RA和SS重叠（RA / SS）。同期检测到的SS（n = 187）病例作为对照。结果：在RA / SS患者中，有46例RA发作SS和12例SS发作RA。 16例患者同时患有RA和SS。与没有SS的RA相比，RA / SS患者有更严重的关节炎。血液学异常，发烧和皮疹的发生率更高; RF，ANA和抗SSA和抗SSB抗体的频率更高（P <0.05）。与原发性SS相比，RA / SS患者年龄较大，患有严重的关节炎，贫血和肺部感染;发烧，皮疹，白细胞减少症，血小板减少症和甲状腺功能亢进症的发生率较低; RF，抗角蛋白抗体，抗周核因子和抗环瓜氨酸抗体的频率较高（P <0.05）。与RA和原发性SS相比，RA / SS患者的RA和SS疾病活动评分更高。结论：RA / SS患者特征鲜明，并发症多，全身受累。另外，在RA / SS中疾病活动性更高。

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