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首页> 外文期刊>RSC Advances >A new electrochemical sensor for the simultaneous determination of guanine and adenine: using a NiAl-layered double hydroxide/graphene oxide-multi wall carbon nanotube modified glassy carbon electrode
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A new electrochemical sensor for the simultaneous determination of guanine and adenine: using a NiAl-layered double hydroxide/graphene oxide-multi wall carbon nanotube modified glassy carbon electrode

机译：一种同时测定鸟嘌呤和腺嘌呤的新型电化学传感器：使用钉层双氢氧化物/氧化石墨烯-多壁碳纳米管修饰的玻碳电极

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摘要

An electrochemical sensor was developed for guanine (GA) and adenine (AD) detection using multiwall carbon nanotubes (MWCNTs) with the hybrid NiAl-layered double hydroxide/graphene oxide (NiAl-LDH/GO) on a glassy carbon electrode (GCE), referred to as MWCNTs/NiAl-LDH/GO/GCE. The modified electrode was used for the simultaneous detection of GA and AD. Electrochemical performances related to the direct electrooxidation of GA and AD at the modified electrode were investigated, showing that their peak currents were greatly enhanced due to the presence of MWCNTs/NiAl-LDH/GO nanohybrids. Also, it was revealed that the oxidation peak potentials of GA and AD on the modified electrode were negatively shifted, leading to the increase of their electrocatalytic activity at the surface of MWCNTs/NiAl-LDH/GO/GCE. The effects of different parameters such as pH, accumulation time, accumulation potential, and scan rate on the sensitivity were investigated too. Determination of purine bases was done by a linear sweep voltammetric (LSV) technique. The linear ranges of 0.010-45 mM, with the detection limit of 3 nM for GA, and 0.08-45 mu M, with the detection limit of 20 nM for AD, were achieved. Finally, the proposed electrochemical sensor was employed for the simultaneous determination of GA and AD in single-strand deoxyribonucleic acid (ssDNA) samples.
机译：开发了一种电化学传感器，用于在玻璃碳电极（GCE）上使用多壁碳纳米管（MWCNT）和混合的NiAl层状双氢氧化物/氧化石墨烯（NiAl-LDH / GO）进行鸟嘌呤（GA）和腺嘌呤（AD）检测，称为MWCNT / NiAl-LDH / GO / GCE。修饰的电极用于同时检测GA和AD。研究了与修饰电极上的GA和AD直接电氧化有关的电化学性能，表明由于存在MWCNTs / NiAl-LDH / GO纳米杂化物，它们的峰值电流大大提高。另外，还发现GA和AD在修饰电极上的氧化峰电位负移，导致它们在MWCNTs / NiAl-LDH / GO / GCE表面的电催化活性增加。还研究了pH，累积时间，累积电势和扫描速率等不同参数对灵敏度的影响。嘌呤碱的测定通过线性扫描伏安法（LSV）进行。对于GA，线性范围为0.010-45 mM，检测极限为3 nM;对于AD，线性范围为0.08-45μM，检测极限为20 nM。最后，提出的电化学传感器用于同时测定单链脱氧核糖核酸（ssDNA）样品中的GA和AD。

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