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首页> 外文期刊>RSC Advances >Effect of PLGA/lecithin hybrid microspheres and beta-tricalcium phosphate granules on the physicochemical properties, in vitro degradation and biocompatibility of calcium phosphate cement
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Effect of PLGA/lecithin hybrid microspheres and beta-tricalcium phosphate granules on the physicochemical properties, in vitro degradation and biocompatibility of calcium phosphate cement

机译：PLGA /卵磷脂杂化微球和β-磷酸三钙颗粒对磷酸钙水泥理化性质，体外降解和生物相容性的影响

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摘要

To improve the biodegradability and tissue ingrowth of calcium phosphate cement (CPC), poly(lactic-co-glycolic acid)/lecithin (PLGA/Lec) hybrid microspheres and isostatically-pressed high-strength betatricalcium phosphate (beta-TCP) granules were incorporated into a CPC matrix. The effect on the mechanical properties, setting time, microstructure and morphology of CPC was studied. Then three samples were selected to investigate the influence of the two additives on the biodegradability and biocompatibility of CPC. The results showed PLGA/Lec microspheres reduced the compressive strength of CPC to some extent, but extended the setting time obviously. Based on adding 10 wt% PLGA/Lec microspheres, 10 wt% beta-TCP granules enhanced the compressive strength and shortened the setting time of CPC. Furthermore, PLGA/Lec microspheres improved the degradability of the cement and created macropores suitable for cells ingrowth in situ in the process of degradation. Both PLGA/Lec microspheres and beta-TCP granules were tested to stimulate the proliferation of mouse bone marrow mesenchymal stem cells (mBMSCs).
机译：为了提高磷酸钙水泥（CPC）的生物降解能力和组织向内生长，加入了聚乳酸-乙醇酸/卵磷脂（PLGA / Lec）杂化微球和等静压的高强度磷酸三磷酸钙（β-TCP）颗粒转化为CPC矩阵。研究了CPC对力学性能，凝固时间，显微组织和形态的影响。然后选择三个样品来研究两种添加剂对CPC的生物降解性和生物相容性的影响。结果表明，PLGA / Lec微球在一定程度上降低了CPC的抗压强度，但明显延长了凝固时间。在添加10 wt％的PLGA / Lec微球的基础上，10 wt％的beta-TCP颗粒提高了抗压强度并缩短了CPC的凝固时间。此外，PLGA / Lec微球改善了水泥的降解性，并产生了适用于细胞降解过程中原位向内生长的大孔。测试PLGA / Lec微球和β-TCP颗粒均能刺激小鼠骨髓间充质干细胞（mBMSC）的增殖。

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