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首页> 外文期刊>RSC Advances >Molecularly imprinted fluorescent chemosensor synthesized using quinoline-modified-beta-cyclodextrin as monomer for spermidine recognition
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Molecularly imprinted fluorescent chemosensor synthesized using quinoline-modified-beta-cyclodextrin as monomer for spermidine recognition

机译：以喹啉修饰的β-环糊精为单体合成的分子印迹荧光化学传感器

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摘要

Polyamines are polycationic amines and playing important functions in the cellular growth and proliferation. Abnormal levels of polyamines in the biological fluids have been related to different diseases including cancers. However, polyamine analysis is a difficult task because there are no chromophores in the polyamine structures. In this study, a novel molecularly imprinted fluorescent chemosensor for spermidine detection has been synthesized using quinoline modified-beta-cyclodextrin as the functional monomer. The imprinted receptors were formed by the interaction between the spermidine and beta-cyclodextrin (beta-CD). The fluorescence of the chemosensor has shown a "Turn-on" response mode which resulted from the increase of the environmental hydrophobicity around the quinoline group due to the inclusion of spermidine in the CD cavity. The chemosensor has selectivity for the spermidine and its structural analogue spermine due to the imprinting effect. In the research, the binding constant of the imprinted membrane was evaluated and the binding mechanism of the MIP was studied by 2D(1)H NMR experiment. The research on spermidine analysis in serum demonstrated the imprinted chemosensor has good application potential in the biological sample analysis.
机译：聚胺是聚阳离子胺，在细胞生长和增殖中起重要作用。生物体液中多胺的异常含量与包括癌症在内的不同疾病有关。但是，聚胺分析是一项艰巨的任务，因为聚胺结构中没有生色团。在这项研究中，使用喹啉修饰的β-环糊精作为功能单体，合成了用于亚精胺检测的新型分子印迹荧光化学传感器。印记的受体是由亚精胺和β-环糊精（β-CD）之间的相互作用形成的。化学传感器的荧光显示出“打开”响应模式，这是由于CD腔中包含亚精胺，导致喹啉基周围的环境疏水性增加所致。由于印迹效应，化学传感器对亚精胺及其结构类似物亚精胺具有选择性。在研究中，通过2D（1）H NMR实验评估了印迹膜的结合常数，并研究了MIP的结合机理。血清亚精胺分析的研究表明，印迹化学传感器在生物样品分析中具有良好的应用潜力。

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